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- W2022764597 abstract "TET/JBP enzymes oxidize 5-methylpyrimidines in DNA. In mammals, the oxidized methylcytosines (oxi-mCs) function as epigenetic marks and likely intermediates in DNA demethylation. Here we present a method based on diglucosylation of 5-hydroxymethylcytosine (5hmC) to simultaneously map 5hmC, 5-formylcytosine, and 5-carboxylcytosine at near-base-pair resolution. We have used the method to map the distribution of oxi-mC across the genome of Coprinopsis cinerea, a basidiomycete that encodes 47 TET/JBP paralogs in a previously unidentified class of DNA transposons. Like 5-methylcytosine residues from which they are derived, oxi-mC modifications are enriched at centromeres, TET/JBP transposons, and multicopy paralogous genes that are not expressed, but rarely mark genes whose expression changes between two developmental stages. Our study provides evidence for the emergence of an epigenetic regulatory system through recruitment of selfish elements in a eukaryotic lineage, and describes a method to map all three different species of oxi-mCs simultaneously." @default.
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- W2022764597 date "2014-11-18" @default.
- W2022764597 modified "2023-10-11" @default.
- W2022764597 title "Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in <i>Coprinopsis cinerea</i>" @default.
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- W2022764597 doi "https://doi.org/10.1073/pnas.1419513111" @default.
- W2022764597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4260599" @default.
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