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• W2022771097 abstract "Sir,We thank Dr Dauby for his interest in our review (Faucette et al., 2015), and share his appreciation of the progress and confidence in the promise of maternal vaccination as a strategy to combat maternal and neonatal infections. Despite the success of selected maternal vaccines, we contend that pregnancy-associated immune modulations could cause suboptimal or qualitatively different vaccine responses. Supporting this notion are the numerous studies showing that both human (Christiansen et al., 1976; Moore et al., 1983; Valdimarsson et al., 1983; Iwatani et al., 1988; Watanabe et al., 1997; Mahmoud et al., 2001; Kraus et al., 2012; Sperling et al., 2012) and mouse pregnancies (Medina et al., 1993; Medina and Kincade, 1994) are associated with substantial modulations in the B cell compartment. Dr Dauby claimed that such changes in B cells during human pregnancy seemed rather limited and did not appear to affect B cell function, as suggested by recent studies showing similar proportions of first and second trimester B cell subsets (Dauby et al., 2014), rate of seroconversion (Sperling et al., 2012) and immunogenicity (Munoz et al., 2014) in response to vaccination in pregnant and non-pregnant women. It is, however, important to note that the proportion values do not provide direct information on the absolute numbers of B cell subsets. Furthermore, seroconversion rate or immunogenicity does not reflect the diversity or quality of the humoral immune repertoire, such as the degree of somatic hypermutation or neutralizing function. Therefore, the impact of pregnancy-associated changes in the B cell compartment on humoral immune function remains to be carefully elucidated.Dr Dauby further suggested that B cell-associated quantitative changes occur only in the third trimester, based on findings from his lab and others (Kraus et al., 2012; Dauby et al., 2014). The reduced numbers of circulating B cells have been well documented in the third trimester, but a number of studies found that the reduction in circulating B cell numbers occurred earlier in pregnancy (Moore et al., 1983; Valdimarsson et al., 1983; Iwatani et al., 1988; Watanabe et al., 1997). Considering that the optimal timing of Tetanus, diphtheria and pertussis vaccination (Tdap) recommended by the Centers for Disease Control and Prevention is between 27 and 36 weeks of gestation (Centers for Disease Control and Prevention, 2013) and that the highest trivalent IIV vaccine response rate was seen in the third trimester (Sperling et al., 2012), the substantial reduction in circulating B cell numbers consistently found in the third trimester is likely to impact vaccine response during this critical window. While many studies on the role of reproductive hormones, such as estrogen, that are implicated in modulating B cell function during pregnancy was conducted in mice, the effect of estrogen on human B cell maturation, albeit indirectly, parallels the findings in mouse B cells (Paavonen et al., 1981). In conclusion, due to the complexity of humoral immune modulation, a paucity of data on the B cell compartment in systemic and mucosal secondary lymphoid organs, which are the inductive sites of vaccine immunity distinct from the circulation, and a lack of molecular and functional assessment of the vaccine-induced antibody repertoire during pregnancy, it is presumptuous to conclude that ‘B cell compartments, including naive and memory B cells, appear poorly affected by pregnancy and response to both neo and recall antigens is intact during pregnancy’. Coupled with the heightened ethical and medical concerns of vaccine safety in pregnancy, it is important to exercise caution and combine clinical readouts with basic immunological insights in the development, evaluation and improvement of maternal vaccines, particularly for less well-studied vaccines and in women susceptible to high-risk pregnancies, such that this promising public health strategy can be made safer and more efficient to broader populations against a wider range of infections." @default.
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• W2022771097 date "2015-02-23" @default.
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• W2022771097 title "Reply: Maternal vaccination: moving the science forward†" @default.
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• W2022771097 doi "https://doi.org/10.1093/humupd/dmv010" @default.
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