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- W2022771415 abstract "The role of regulatory T cells, (Treg) in human cancer and HIV-1 infections has been under intense scrutiny. While the lack of a marker specific for human Treg has made it challenging to phenotype these cells, combinations of several markers and functional attributes of Treg have made it possible to assess their contributions to immune homeostasis in health and disease. Treg diversity and their plasticity create a challenge in deciding whether they are beneficial to the host by down-regulating excessive immune activation or are responsible for adverse effects such as suppression of anti-tumor immune responses resulting in promotion of tumor growth. Treg are emerging as active participants in several biochemical pathways involved in immune regulation. This review attempts to integrate current information about human Treg in respect to their activities in cancer and HIV-1. The goal is to evaluate the potential of Treg as targets for future immune or pharmacologic therapies for cancer or HIV-1 infections." @default.
- W2022771415 created "2016-06-24" @default.
- W2022771415 creator A5050172772 @default.
- W2022771415 date "2014-11-12" @default.
- W2022771415 modified "2023-10-04" @default.
- W2022771415 title "Clinical Impact of Regulatory T cells (Treg) in Cancer and HIV" @default.
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- W2022771415 doi "https://doi.org/10.1007/s12307-014-0159-1" @default.
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