FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022772870> ?p ?o ?g. }

• W2022772870 endingPage "2558" @default.
• W2022772870 startingPage "2554" @default.
• W2022772870 abstract "Abstract Chronic lymphocytic leukemia (CLL) is an incurable progressive disease for which new therapies are required. Therapy with monoclonal antibodies (mAbs) has improved the outcome of patients with CLL, making further investigation of novel antibodies directed against alternative and specific targets on B cells an important area of translational research. We now describe functional properties of an antagonistic humanized mAb to CD74, milatuzumab, showing that milatuzumab combined with a crosslinking antibody induces cytotoxicity in vitro in CLL cells in a caspase- and stromal-independent manner associated with aggregation of CD74 on the cell surface. Furthermore, incorporation of milatuzumab into an immunoliposome induces even more of a cytotoxic response than in vitro crosslinking, representing a novel therapeutic formulation for this mAb. Based on these data, future development of the milatuzumab-immunoliposome formulation as a therapeutic agent for CLL is warranted." @default.
• W2022772870 created "2016-06-24" @default.
• W2022772870 creator A5000921376 @default.
• W2022772870 creator A5003890903 @default.
• W2022772870 creator A5007648913 @default.
• W2022772870 creator A5009397786 @default.
• W2022772870 creator A5016110873 @default.
• W2022772870 creator A5026993490 @default.
• W2022772870 creator A5040022220 @default.
• W2022772870 creator A5048355990 @default.
• W2022772870 creator A5054228072 @default.
• W2022772870 creator A5055443268 @default.
• W2022772870 creator A5078060521 @default.
• W2022772870 date "2010-10-07" @default.
• W2022772870 modified "2023-10-17" @default.
• W2022772870 title "Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells" @default.
• W2022772870 cites W1990910542 @default.
• W2022772870 cites W2009593167 @default.
• W2022772870 cites W2015147905 @default.
• W2022772870 cites W2024520647 @default.
• W2022772870 cites W2040598177 @default.
• W2022772870 cites W2049090395 @default.
• W2022772870 cites W2050704142 @default.
• W2022772870 cites W2054409932 @default.
• W2022772870 cites W2090279266 @default.
• W2022772870 cites W2112795579 @default.
• W2022772870 cites W2125134816 @default.
• W2022772870 cites W2151177887 @default.
• W2022772870 cites W2158508282 @default.
• W2022772870 cites W2161048718 @default.
• W2022772870 cites W2168267840 @default.
• W2022772870 cites W2169087490 @default.
• W2022772870 cites W2275948481 @default.
• W2022772870 cites W60865865 @default.
• W2022772870 doi "https://doi.org/10.1182/blood-2009-11-253203" @default.
• W2022772870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2953888" @default.
• W2022772870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20574049" @default.
• W2022772870 hasPublicationYear "2010" @default.
• W2022772870 type Work @default.
• W2022772870 sameAs 2022772870 @default.
• W2022772870 citedByCount "39" @default.
• W2022772870 countsByYear W20227728702012 @default.
• W2022772870 countsByYear W20227728702013 @default.
• W2022772870 countsByYear W20227728702014 @default.
• W2022772870 countsByYear W20227728702015 @default.
• W2022772870 countsByYear W20227728702016 @default.
• W2022772870 countsByYear W20227728702017 @default.
• W2022772870 countsByYear W20227728702018 @default.
• W2022772870 countsByYear W20227728702019 @default.
• W2022772870 countsByYear W20227728702022 @default.
• W2022772870 countsByYear W20227728702023 @default.
• W2022772870 crossrefType "journal-article" @default.
• W2022772870 hasAuthorship W2022772870A5000921376 @default.
• W2022772870 hasAuthorship W2022772870A5003890903 @default.
• W2022772870 hasAuthorship W2022772870A5007648913 @default.
• W2022772870 hasAuthorship W2022772870A5009397786 @default.
• W2022772870 hasAuthorship W2022772870A5016110873 @default.
• W2022772870 hasAuthorship W2022772870A5026993490 @default.
• W2022772870 hasAuthorship W2022772870A5040022220 @default.
• W2022772870 hasAuthorship W2022772870A5048355990 @default.
• W2022772870 hasAuthorship W2022772870A5054228072 @default.
• W2022772870 hasAuthorship W2022772870A5055443268 @default.
• W2022772870 hasAuthorship W2022772870A5078060521 @default.
• W2022772870 hasBestOaLocation W20227728701 @default.
• W2022772870 hasConcept C109316439 @default.
• W2022772870 hasConcept C119997001 @default.
• W2022772870 hasConcept C154317977 @default.
• W2022772870 hasConcept C159654299 @default.
• W2022772870 hasConcept C16930146 @default.
• W2022772870 hasConcept C170627219 @default.
• W2022772870 hasConcept C185592680 @default.
• W2022772870 hasConcept C202751555 @default.
• W2022772870 hasConcept C203014093 @default.
• W2022772870 hasConcept C2777938653 @default.
• W2022772870 hasConcept C2778461978 @default.
• W2022772870 hasConcept C502942594 @default.
• W2022772870 hasConcept C542903549 @default.
• W2022772870 hasConcept C55493867 @default.
• W2022772870 hasConcept C71924100 @default.
• W2022772870 hasConceptScore W2022772870C109316439 @default.
• W2022772870 hasConceptScore W2022772870C119997001 @default.
• W2022772870 hasConceptScore W2022772870C154317977 @default.
• W2022772870 hasConceptScore W2022772870C159654299 @default.
• W2022772870 hasConceptScore W2022772870C16930146 @default.
• W2022772870 hasConceptScore W2022772870C170627219 @default.
• W2022772870 hasConceptScore W2022772870C185592680 @default.
• W2022772870 hasConceptScore W2022772870C202751555 @default.
• W2022772870 hasConceptScore W2022772870C203014093 @default.
• W2022772870 hasConceptScore W2022772870C2777938653 @default.
• W2022772870 hasConceptScore W2022772870C2778461978 @default.
• W2022772870 hasConceptScore W2022772870C502942594 @default.
• W2022772870 hasConceptScore W2022772870C542903549 @default.
• W2022772870 hasConceptScore W2022772870C55493867 @default.
• W2022772870 hasConceptScore W2022772870C71924100 @default.
• W2022772870 hasIssue "14" @default.
• W2022772870 hasLocation W20227728701 @default.
• W2022772870 hasLocation W20227728702 @default.
• W2022772870 hasLocation W20227728703 @default.

• next