Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022773122> ?p ?o ?g. }
- W2022773122 endingPage "304" @default.
- W2022773122 startingPage "296" @default.
- W2022773122 abstract "Signaling pathways mediating Epstein–Barr virus (EBV) reactivation by Ag-bound B-cell receptor (BCR) were analyzed using a panel of 80 protein kinase inhibitors. Broad range protein kinase inhibitors Staurosporine, K252A, and PKC-412 significantly reduced the EBV genome copy numbers measured 48 h after reactivation perhaps due to their higher toxicity. In addition, selected inhibitors of the phosphatidylinositol-3-kinase (PI3K), protein kinase C (PKC), mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways, glycogen synthase kinase 3β (GSK-3β), platelet-derived growth factor receptor-associated tyrosine kinase (PDGFRK), and epidermal growth factor receptor-associated tyrosine kinase (EGFRK) significantly reduced the EBV genome copy numbers. Of those, only U0126 and Erbstatin analog, which inhibit MAPK pathway and EGFRK, respectively, did not inhibit viral reactivation assessed by expression of the EBV early protein, EA-D. None of the tested compounds, except for K252A, affected the activity of the EBV-encoded protein kinase in vitro. These results show that EBV reactivation induced by BCR signaling is mainly mediated through PI3K and PKC, whereas MAPK might be involved in later stages of viral replication." @default.
- W2022773122 created "2016-06-24" @default.
- W2022773122 creator A5039343323 @default.
- W2022773122 creator A5043739505 @default.
- W2022773122 creator A5055668062 @default.
- W2022773122 creator A5059278886 @default.
- W2022773122 date "2012-12-01" @default.
- W2022773122 modified "2023-10-17" @default.
- W2022773122 title "Protein kinase inhibitors that inhibit induction of lytic program and replication of Epstein–Barr virus" @default.
- W2022773122 cites W1241220757 @default.
- W2022773122 cites W1529396499 @default.
- W2022773122 cites W1743579359 @default.
- W2022773122 cites W1785108662 @default.
- W2022773122 cites W1818313483 @default.
- W2022773122 cites W1838401124 @default.
- W2022773122 cites W1898707643 @default.
- W2022773122 cites W1974817469 @default.
- W2022773122 cites W1981785841 @default.
- W2022773122 cites W1985760862 @default.
- W2022773122 cites W1999319877 @default.
- W2022773122 cites W2001813004 @default.
- W2022773122 cites W2004668555 @default.
- W2022773122 cites W2006264155 @default.
- W2022773122 cites W2009438033 @default.
- W2022773122 cites W2018011543 @default.
- W2022773122 cites W2025710331 @default.
- W2022773122 cites W2026795477 @default.
- W2022773122 cites W2030302506 @default.
- W2022773122 cites W2032809973 @default.
- W2022773122 cites W2035221880 @default.
- W2022773122 cites W2040541452 @default.
- W2022773122 cites W2043051204 @default.
- W2022773122 cites W2052383020 @default.
- W2022773122 cites W2052603677 @default.
- W2022773122 cites W2052750950 @default.
- W2022773122 cites W2055397341 @default.
- W2022773122 cites W2058262035 @default.
- W2022773122 cites W2060630008 @default.
- W2022773122 cites W2061112273 @default.
- W2022773122 cites W2064065183 @default.
- W2022773122 cites W2064846451 @default.
- W2022773122 cites W2069855944 @default.
- W2022773122 cites W2075443188 @default.
- W2022773122 cites W2080740689 @default.
- W2022773122 cites W2080838168 @default.
- W2022773122 cites W2086262311 @default.
- W2022773122 cites W2093703320 @default.
- W2022773122 cites W2093881154 @default.
- W2022773122 cites W2096194507 @default.
- W2022773122 cites W2096682430 @default.
- W2022773122 cites W2106227497 @default.
- W2022773122 cites W2108233169 @default.
- W2022773122 cites W2109840090 @default.
- W2022773122 cites W2112599054 @default.
- W2022773122 cites W2114576862 @default.
- W2022773122 cites W2126082558 @default.
- W2022773122 cites W2134971124 @default.
- W2022773122 cites W2137521306 @default.
- W2022773122 cites W2139804994 @default.
- W2022773122 cites W2146659187 @default.
- W2022773122 cites W2149058786 @default.
- W2022773122 cites W2155046255 @default.
- W2022773122 cites W2160401113 @default.
- W2022773122 cites W2164889663 @default.
- W2022773122 cites W2166912626 @default.
- W2022773122 cites W2169982546 @default.
- W2022773122 cites W2401069193 @default.
- W2022773122 cites W2418978545 @default.
- W2022773122 cites W4241702858 @default.
- W2022773122 doi "https://doi.org/10.1016/j.antiviral.2012.09.021" @default.
- W2022773122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3513622" @default.
- W2022773122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23058855" @default.
- W2022773122 hasPublicationYear "2012" @default.
- W2022773122 type Work @default.
- W2022773122 sameAs 2022773122 @default.
- W2022773122 citedByCount "32" @default.
- W2022773122 countsByYear W20227731222013 @default.
- W2022773122 countsByYear W20227731222014 @default.
- W2022773122 countsByYear W20227731222015 @default.
- W2022773122 countsByYear W20227731222016 @default.
- W2022773122 countsByYear W20227731222018 @default.
- W2022773122 countsByYear W20227731222019 @default.
- W2022773122 countsByYear W20227731222020 @default.
- W2022773122 countsByYear W20227731222021 @default.
- W2022773122 countsByYear W20227731222022 @default.
- W2022773122 countsByYear W20227731222023 @default.
- W2022773122 crossrefType "journal-article" @default.
- W2022773122 hasAuthorship W2022773122A5039343323 @default.
- W2022773122 hasAuthorship W2022773122A5043739505 @default.
- W2022773122 hasAuthorship W2022773122A5055668062 @default.
- W2022773122 hasAuthorship W2022773122A5059278886 @default.
- W2022773122 hasBestOaLocation W20227731222 @default.
- W2022773122 hasConcept C101544691 @default.
- W2022773122 hasConcept C124160383 @default.
- W2022773122 hasConcept C137361374 @default.
- W2022773122 hasConcept C153911025 @default.
- W2022773122 hasConcept C159479382 @default.
- W2022773122 hasConcept C161238802 @default.