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• W2022773184 abstract "The effects of diazo-oxo-norleucine (DON) on synthesis of palatal glycoproteins and epithelial cell adhesion in vitro were investigated. Adhesion between developing homologous rat palatal epithelia in vitro was prevented by culturing day 15 shelves in the presence of DON (20 μg/ml). Binding of [3H]concanavalin A (ConA) to the epithelial surface of palatal shelves in vitro was dramatically reduced by DON. DON-induced inhibition of adhesion as well as the reduction of [3H]ConA binding was prevented by concurrent glutamine (10 mM) or glucosamine (10 mM) administration. DON substantially inhibited the incorporation of [3H]fucose, Na235SO4, and [3H]-glucosamine into palatal macromolecular components as shown autoradiographically and biochemically. These data suggest that DON inhibits palatal adhesion in vitro by blocking the synthesis and secretion of carbohydrate-rich macromolecules associated with the cell surface." @default.
• W2022773184 created "2016-06-24" @default.
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• W2022773184 date "1977-03-01" @default.
• W2022773184 modified "2023-10-14" @default.
• W2022773184 title "Inhibition by diazo-oxo-norleucine (DON) of rat palatal glycoprotein synthesis and epithelial cell adhesion in vitro" @default.
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• W2022773184 doi "https://doi.org/10.1016/0014-4827(77)90149-5" @default.
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