Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022773665> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2022773665 abstract "BackgroundMaternal diabetes influences fetal pancreas development. As there are some controversial reports, we studied the morphometric changes of the fetal insular pancreas and insulin immunostain of beta cells as well as the proliferative activity of insular cells in 21-day-old fetuses from control, diabetic, and insulin-treated diabetic pregnant rats.MethodsStreptozotocin was injected into 7-day-pregnant rats (controls were not injected). Some rats were either left untreated (diabetic) or injected with insulin. Animals were killed at 21 days of gestation. Fetal pancreas were fixed in toto for the morphometry and immunohistochemistry studies using anti-insulin, anti-Ki-67 and anti-proliferating cell nuclear antigen (PCNA) antibodies.ResultsDiabetic status was determined by measuring maternal and fetal serum glucose and insulin levels. The morphometric studies showed hyperplasia of the diabetic fetal insular tissue which had not been normalized by insulin therapy. Diabetes caused an increase of both insulin-positive and insulin-negative cells. The increase in insulin-positive cells was not corrected by insulin treatment, although the number of non-beta cells became normal. The nuclear area in beta cells increased in diabetic rats but was not corrected by insulin. The cytoplasmic area decreased in diabetic rats and was normalized by insulin administration. Diabetes increased the expression of the nuclear antigen Ki-67 in fetal insular pancreas, and insulin treatment returned it to the normal state.ConclusionsMaternal diabetes leads to hyperstimulation of fetal beta cells, with increased proliferative activity. Insulin administration to the dams corrects some of the changes observed. Anat. Rec. 251:173–180, 1998. © 1998 Wiley-Liss, Inc." @default.
- W2022773665 created "2016-06-24" @default.
- W2022773665 creator A5020031644 @default.
- W2022773665 creator A5029158200 @default.
- W2022773665 creator A5029303884 @default.
- W2022773665 creator A5038527520 @default.
- W2022773665 creator A5081936189 @default.
- W2022773665 creator A5090932186 @default.
- W2022773665 date "1998-06-01" @default.
- W2022773665 modified "2023-10-14" @default.
- W2022773665 title "Immunohistochemical and morphometric studies of the fetal pancreas in diabetic pregnant rats. Effects of insulin administration" @default.
- W2022773665 cites W1975624480 @default.
- W2022773665 cites W1976691163 @default.
- W2022773665 cites W1983498402 @default.
- W2022773665 cites W2005656127 @default.
- W2022773665 cites W2008346669 @default.
- W2022773665 cites W2010023748 @default.
- W2022773665 cites W2011058094 @default.
- W2022773665 cites W2016508411 @default.
- W2022773665 cites W2017797235 @default.
- W2022773665 cites W2019073316 @default.
- W2022773665 cites W2028727556 @default.
- W2022773665 cites W2033936238 @default.
- W2022773665 cites W2046675601 @default.
- W2022773665 cites W2050073835 @default.
- W2022773665 cites W2051931433 @default.
- W2022773665 cites W2069329440 @default.
- W2022773665 cites W2074037686 @default.
- W2022773665 cites W2077921929 @default.
- W2022773665 cites W2079866773 @default.
- W2022773665 cites W2088610579 @default.
- W2022773665 cites W2096428903 @default.
- W2022773665 cites W2097533338 @default.
- W2022773665 cites W2102812140 @default.
- W2022773665 cites W2112852386 @default.
- W2022773665 cites W2124314287 @default.
- W2022773665 cites W2151716122 @default.
- W2022773665 cites W2155643713 @default.
- W2022773665 cites W2325066311 @default.
- W2022773665 cites W4211048358 @default.
- W2022773665 cites W74309943 @default.
- W2022773665 cites W2092169341 @default.
- W2022773665 doi "https://doi.org/10.1002/(sici)1097-0185(199806)251:2<173::aid-ar4>3.0.co;2-#" @default.
- W2022773665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9624446" @default.
- W2022773665 hasPublicationYear "1998" @default.
- W2022773665 type Work @default.
- W2022773665 sameAs 2022773665 @default.
- W2022773665 citedByCount "5" @default.
- W2022773665 countsByYear W20227736652012 @default.
- W2022773665 crossrefType "journal-article" @default.
- W2022773665 hasAuthorship W2022773665A5020031644 @default.
- W2022773665 hasAuthorship W2022773665A5029158200 @default.
- W2022773665 hasAuthorship W2022773665A5029303884 @default.
- W2022773665 hasAuthorship W2022773665A5038527520 @default.
- W2022773665 hasAuthorship W2022773665A5081936189 @default.
- W2022773665 hasAuthorship W2022773665A5090932186 @default.
- W2022773665 hasConcept C126322002 @default.
- W2022773665 hasConcept C134018914 @default.
- W2022773665 hasConcept C172680121 @default.
- W2022773665 hasConcept C204232928 @default.
- W2022773665 hasConcept C2778764654 @default.
- W2022773665 hasConcept C2779234561 @default.
- W2022773665 hasConcept C2779280383 @default.
- W2022773665 hasConcept C2779306644 @default.
- W2022773665 hasConcept C54355233 @default.
- W2022773665 hasConcept C555293320 @default.
- W2022773665 hasConcept C71924100 @default.
- W2022773665 hasConcept C86803240 @default.
- W2022773665 hasConceptScore W2022773665C126322002 @default.
- W2022773665 hasConceptScore W2022773665C134018914 @default.
- W2022773665 hasConceptScore W2022773665C172680121 @default.
- W2022773665 hasConceptScore W2022773665C204232928 @default.
- W2022773665 hasConceptScore W2022773665C2778764654 @default.
- W2022773665 hasConceptScore W2022773665C2779234561 @default.
- W2022773665 hasConceptScore W2022773665C2779280383 @default.
- W2022773665 hasConceptScore W2022773665C2779306644 @default.
- W2022773665 hasConceptScore W2022773665C54355233 @default.
- W2022773665 hasConceptScore W2022773665C555293320 @default.
- W2022773665 hasConceptScore W2022773665C71924100 @default.
- W2022773665 hasConceptScore W2022773665C86803240 @default.
- W2022773665 hasLocation W20227736651 @default.
- W2022773665 hasOpenAccess W2022773665 @default.
- W2022773665 hasPrimaryLocation W20227736651 @default.
- W2022773665 hasRelatedWork W1998091002 @default.
- W2022773665 hasRelatedWork W2002319675 @default.
- W2022773665 hasRelatedWork W2011196179 @default.
- W2022773665 hasRelatedWork W2016526162 @default.
- W2022773665 hasRelatedWork W2034399039 @default.
- W2022773665 hasRelatedWork W2066124485 @default.
- W2022773665 hasRelatedWork W2094857026 @default.
- W2022773665 hasRelatedWork W2140621396 @default.
- W2022773665 hasRelatedWork W2314464925 @default.
- W2022773665 hasRelatedWork W2406442320 @default.
- W2022773665 isParatext "false" @default.
- W2022773665 isRetracted "false" @default.
- W2022773665 magId "2022773665" @default.
- W2022773665 workType "article" @default.