Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022776084> ?p ?o ?g. }
- W2022776084 endingPage "52" @default.
- W2022776084 startingPage "42" @default.
- W2022776084 abstract "Kidney involvement affects 40-60% of patients with lupus, and is responsible for significant morbidity and mortality. Using depletion approaches, several studies have suggested that macrophages may play a key role in the pathogenesis of lupus nephritis. However, off target effects of macrophage depletion, such as altered hematopoiesis or enhanced autoantibody production, impeded the determination of a conclusive relationship. In this study, we investigated the role of macrophages in mice receiving rabbit anti-glomerular antibodies, or nephrotoxic serum (NTS), an experimental model which closely mimics the immune complex mediated disease seen in murine and human lupus nephritis. GW2580, a selective inhibitor of the colony stimulating factor-1 (CSF-1) receptor kinase, was used for macrophage depletion. We found that GW2580-treated, NTS challenged mice did not develop the increased levels of proteinuria, serum creatinine, and BUN seen in control-treated, NTS challenged mice. NTS challenged mice exhibited significantly increased kidney expression of inflammatory cytokines including RANTES, IP-10, VCAM-1 and iNOS, whereas GW2580-treated mice were protected from the robust expression of these inflammatory cytokines that are associated with lupus nephritis. Quantification of macrophage related gene expression, flow cytometry analysis of kidney single cell suspensions, and immunofluorescence staining confirmed the depletion of macrophages in GW2580-treated mice, specifically within renal glomeruli. Our results strongly implicate a specific and necessary role for macrophages in the development of immune glomerulonephritis mediated by pathogenic antibodies, and support the development of macrophage targeting approaches for the treatment of lupus nephritis." @default.
- W2022776084 created "2016-06-24" @default.
- W2022776084 creator A5057036692 @default.
- W2022776084 creator A5060336953 @default.
- W2022776084 creator A5078972851 @default.
- W2022776084 creator A5079662311 @default.
- W2022776084 creator A5080291739 @default.
- W2022776084 creator A5088498253 @default.
- W2022776084 date "2015-02-01" @default.
- W2022776084 modified "2023-10-16" @default.
- W2022776084 title "Macrophage depletion ameliorates nephritis induced by pathogenic antibodies" @default.
- W2022776084 cites W1516554807 @default.
- W2022776084 cites W1531875703 @default.
- W2022776084 cites W1831776830 @default.
- W2022776084 cites W1881636432 @default.
- W2022776084 cites W1960367851 @default.
- W2022776084 cites W1969520387 @default.
- W2022776084 cites W1970264868 @default.
- W2022776084 cites W1972921461 @default.
- W2022776084 cites W1988212011 @default.
- W2022776084 cites W1996055704 @default.
- W2022776084 cites W2002169146 @default.
- W2022776084 cites W2003346334 @default.
- W2022776084 cites W2003820403 @default.
- W2022776084 cites W2006826186 @default.
- W2022776084 cites W2010957725 @default.
- W2022776084 cites W2024725966 @default.
- W2022776084 cites W2025850686 @default.
- W2022776084 cites W2026578487 @default.
- W2022776084 cites W2031603575 @default.
- W2022776084 cites W2045152845 @default.
- W2022776084 cites W2047015493 @default.
- W2022776084 cites W2053130016 @default.
- W2022776084 cites W2053968886 @default.
- W2022776084 cites W2055348159 @default.
- W2022776084 cites W2056698286 @default.
- W2022776084 cites W2072887917 @default.
- W2022776084 cites W2080882856 @default.
- W2022776084 cites W2082681418 @default.
- W2022776084 cites W2100772783 @default.
- W2022776084 cites W2103353049 @default.
- W2022776084 cites W2105156168 @default.
- W2022776084 cites W2115736737 @default.
- W2022776084 cites W2117605850 @default.
- W2022776084 cites W2118495715 @default.
- W2022776084 cites W2119373925 @default.
- W2022776084 cites W2129861156 @default.
- W2022776084 cites W2132866888 @default.
- W2022776084 cites W2144242611 @default.
- W2022776084 cites W2146183794 @default.
- W2022776084 cites W2149464773 @default.
- W2022776084 cites W2150575847 @default.
- W2022776084 cites W2151049082 @default.
- W2022776084 cites W2153406260 @default.
- W2022776084 cites W2156249237 @default.
- W2022776084 cites W2157460346 @default.
- W2022776084 cites W2159114783 @default.
- W2022776084 cites W2159686917 @default.
- W2022776084 cites W2165892104 @default.
- W2022776084 cites W2404863363 @default.
- W2022776084 doi "https://doi.org/10.1016/j.jaut.2014.11.007" @default.
- W2022776084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4323927" @default.
- W2022776084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25554644" @default.
- W2022776084 hasPublicationYear "2015" @default.
- W2022776084 type Work @default.
- W2022776084 sameAs 2022776084 @default.
- W2022776084 citedByCount "72" @default.
- W2022776084 countsByYear W20227760842015 @default.
- W2022776084 countsByYear W20227760842016 @default.
- W2022776084 countsByYear W20227760842017 @default.
- W2022776084 countsByYear W20227760842018 @default.
- W2022776084 countsByYear W20227760842019 @default.
- W2022776084 countsByYear W20227760842020 @default.
- W2022776084 countsByYear W20227760842021 @default.
- W2022776084 countsByYear W20227760842022 @default.
- W2022776084 countsByYear W20227760842023 @default.
- W2022776084 crossrefType "journal-article" @default.
- W2022776084 hasAuthorship W2022776084A5057036692 @default.
- W2022776084 hasAuthorship W2022776084A5060336953 @default.
- W2022776084 hasAuthorship W2022776084A5078972851 @default.
- W2022776084 hasAuthorship W2022776084A5079662311 @default.
- W2022776084 hasAuthorship W2022776084A5080291739 @default.
- W2022776084 hasAuthorship W2022776084A5088498253 @default.
- W2022776084 hasBestOaLocation W20227760842 @default.
- W2022776084 hasConcept C126322002 @default.
- W2022776084 hasConcept C159654299 @default.
- W2022776084 hasConcept C202751555 @default.
- W2022776084 hasConcept C203014093 @default.
- W2022776084 hasConcept C2776912625 @default.
- W2022776084 hasConcept C2777058396 @default.
- W2022776084 hasConcept C2778474638 @default.
- W2022776084 hasConcept C2778690821 @default.
- W2022776084 hasConcept C2779134260 @default.
- W2022776084 hasConcept C2779244956 @default.
- W2022776084 hasConcept C2779912601 @default.
- W2022776084 hasConcept C2780091579 @default.
- W2022776084 hasConcept C2780368995 @default.
- W2022776084 hasConcept C55493867 @default.