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• W2022776385 abstract "Skin aging is a multifactorial process leading to structural and physiological changes. Protein modifications are known to play here an important role. Since collagen is the most abundant protein in the extracellular matrix of the skin and due to its slow turnover rates it is a frequent target of modifications by reactive compounds. Using skin biopsies of young and old mice we demonstrated that advanced glycation end products (AGEs), such as argpyrimidine and pentosidine, accumulate in aged skin, whereas protein carbonylation is unchanged. To investigate whether this discrepancy in accumulation is the result of an increased formation or due to reduced degradation we used modified collagen type I in in vitro experiments and tested for proteolytic susceptibility. We were able to show that collagenase is able to degrade oxidized and AGE-modified collagen. However, if collagen is cross-linked heavily, collagenase is unable to degrade the modified collagen. Cross-linking of collagen is preferentially taking place in collagen fibers treated with glycoxidizing agents. In summary, the low presence of oxidized collagen in aged skin seems to be the result of a sufficient degradation by collagenases, whereas the reason of the accumulation of AGE-modified collagen is at least partially an insufficient degradation." @default.
• W2022776385 created "2016-06-24" @default.
• W2022776385 creator A5032958494 @default.
• W2022776385 creator A5087695782 @default.
• W2022776385 date "2014-01-01" @default.
• W2022776385 modified "2023-09-23" @default.
• W2022776385 title "Degradation of oxidized and glycoxidized collagen: Role of collagen cross-linking" @default.
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• W2022776385 doi "https://doi.org/10.1016/j.abb.2013.12.007" @default.
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