FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022778146> ?p ?o ?g. }

• W2022778146 endingPage "9" @default.
• W2022778146 startingPage "1" @default.
• W2022778146 abstract "Polymer micelles are promising drug delivery vehicles for the delivery of anticancer agents to tumors. Often, anticancer drugs display potent cytotoxic effects towards cancer cells but are too hydrophobic to be administered in the clinic as a free drug. To address this problem, a polymer micelle was designed using a triblock copolymer (ITP-101) that enables hydrophobic drugs to be encapsulated. An SN-38 encapsulated micelle, IT-141, was prepared that exhibited potent in vitro cytotoxicity against a wide array of cancer cell lines. In a mouse model, pharmacokinetic analysis revealed that IT-141 had a much longer circulation time, plasma exposure, and tumor exposure compared to irinotecan. IT-141 was also superior to irinotecan in terms of antitumor activity, exhibiting greater tumor inhibition in HT-29 and HCT116 colorectal cancer xenograft models at half the dose of irinotecan. The antitumor effect of IT-141 was dose-dependent and caused complete growth inhibition and tumor regression at well-tolerated doses. Varying the specific concentration of SN-38 within the IT-141 micelle had no detectible effect on this antitumor activity, indicating no differences in activity between different IT-141 formulations. In summary, IT-141 is a potent micelle-based chemotherapy that holds promise for the treatment of colorectal cancer." @default.
• W2022778146 created "2016-06-24" @default.
• W2022778146 creator A5004436172 @default.
• W2022778146 creator A5015345725 @default.
• W2022778146 creator A5019761569 @default.
• W2022778146 creator A5027382624 @default.
• W2022778146 creator A5041619584 @default.
• W2022778146 creator A5050041417 @default.
• W2022778146 creator A5087620519 @default.
• W2022778146 date "2011-12-06" @default.
• W2022778146 modified "2023-10-16" @default.
• W2022778146 title "IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models" @default.
• W2022778146 cites W1963527493 @default.
• W2022778146 cites W1983212741 @default.
• W2022778146 cites W2000941201 @default.
• W2022778146 cites W200700132 @default.
• W2022778146 cites W2013683557 @default.
• W2022778146 cites W2015587866 @default.
• W2022778146 cites W2016156919 @default.
• W2022778146 cites W2024873626 @default.
• W2022778146 cites W2027137358 @default.
• W2022778146 cites W2027401476 @default.
• W2022778146 cites W2032535564 @default.
• W2022778146 cites W2036172570 @default.
• W2022778146 cites W2048189382 @default.
• W2022778146 cites W2048363327 @default.
• W2022778146 cites W2059224614 @default.
• W2022778146 cites W2063316727 @default.
• W2022778146 cites W2063414742 @default.
• W2022778146 cites W2069172812 @default.
• W2022778146 cites W2070838947 @default.
• W2022778146 cites W2079240371 @default.
• W2022778146 cites W2082587127 @default.
• W2022778146 cites W2086646496 @default.
• W2022778146 cites W2094864265 @default.
• W2022778146 cites W2099758152 @default.
• W2022778146 cites W2102273204 @default.
• W2022778146 cites W2112927879 @default.
• W2022778146 cites W2118844383 @default.
• W2022778146 cites W2122517878 @default.
• W2022778146 cites W2133744014 @default.
• W2022778146 cites W2151220339 @default.
• W2022778146 cites W2153691074 @default.
• W2022778146 cites W2158244026 @default.
• W2022778146 cites W2158734599 @default.
• W2022778146 cites W4243955582 @default.
• W2022778146 cites W4246661961 @default.
• W2022778146 doi "https://doi.org/10.1155/2011/869027" @default.
• W2022778146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3236496" @default.
• W2022778146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22187652" @default.
• W2022778146 hasPublicationYear "2011" @default.
• W2022778146 type Work @default.
• W2022778146 sameAs 2022778146 @default.
• W2022778146 citedByCount "18" @default.
• W2022778146 countsByYear W20227781462013 @default.
• W2022778146 countsByYear W20227781462014 @default.
• W2022778146 countsByYear W20227781462015 @default.
• W2022778146 countsByYear W20227781462017 @default.
• W2022778146 countsByYear W20227781462019 @default.
• W2022778146 countsByYear W20227781462020 @default.
• W2022778146 countsByYear W20227781462021 @default.
• W2022778146 countsByYear W20227781462022 @default.
• W2022778146 crossrefType "journal-article" @default.
• W2022778146 hasAuthorship W2022778146A5004436172 @default.
• W2022778146 hasAuthorship W2022778146A5015345725 @default.
• W2022778146 hasAuthorship W2022778146A5019761569 @default.
• W2022778146 hasAuthorship W2022778146A5027382624 @default.
• W2022778146 hasAuthorship W2022778146A5041619584 @default.
• W2022778146 hasAuthorship W2022778146A5050041417 @default.
• W2022778146 hasAuthorship W2022778146A5087620519 @default.
• W2022778146 hasBestOaLocation W20227781461 @default.
• W2022778146 hasConcept C11268172 @default.
• W2022778146 hasConcept C112705442 @default.
• W2022778146 hasConcept C121608353 @default.
• W2022778146 hasConcept C126322002 @default.
• W2022778146 hasConcept C178790620 @default.
• W2022778146 hasConcept C184651966 @default.
• W2022778146 hasConcept C185592680 @default.
• W2022778146 hasConcept C202751555 @default.
• W2022778146 hasConcept C2779820397 @default.
• W2022778146 hasConcept C2780035454 @default.
• W2022778146 hasConcept C2780259306 @default.
• W2022778146 hasConcept C2780508388 @default.
• W2022778146 hasConcept C502942594 @default.
• W2022778146 hasConcept C526805850 @default.
• W2022778146 hasConcept C55493867 @default.
• W2022778146 hasConcept C71924100 @default.
• W2022778146 hasConcept C98274493 @default.
• W2022778146 hasConceptScore W2022778146C11268172 @default.
• W2022778146 hasConceptScore W2022778146C112705442 @default.
• W2022778146 hasConceptScore W2022778146C121608353 @default.
• W2022778146 hasConceptScore W2022778146C126322002 @default.
• W2022778146 hasConceptScore W2022778146C178790620 @default.
• W2022778146 hasConceptScore W2022778146C184651966 @default.
• W2022778146 hasConceptScore W2022778146C185592680 @default.
• W2022778146 hasConceptScore W2022778146C202751555 @default.
• W2022778146 hasConceptScore W2022778146C2779820397 @default.
• W2022778146 hasConceptScore W2022778146C2780035454 @default.

• next