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• W2022778360 abstract "Introduction . In the first 48 hours of ventilating patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a multipronged approach including packed red blood cell (PRBC) transfusion is undertaken to maintain oxygen delivery. Hypothesis . We hypothesized children with ALI/ARDS transfused within 48 hours of initiating mechanical ventilation would have worse outcome. The course of 34 transfused patients was retrospectively compared to 45 nontransfused control patients admitted to the PICU at Helen DeVos Children’s Hospital between January 1st 2008 and December 31st 2009. Results . Mean hemoglobin (Hb) prior to transfusion was 8.2 g/dl compared to 10.1 g/dl in control. P/F ratio decreased from<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mn>135.4</mml:mn><mml:mo>±</mml:mo><mml:mn>7.5</mml:mn></mml:mrow></mml:math>to<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mn>116.5</mml:mn><mml:mo>±</mml:mo><mml:mn>8.8</mml:mn></mml:mrow></mml:math>in transfused but increased from<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mn>148.0</mml:mn><mml:mo>±</mml:mo><mml:mn>8.0</mml:mn></mml:mrow></mml:math>to<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mn>190.4</mml:mn><mml:mo>±</mml:mo><mml:mn>17.8</mml:mn></mml:mrow></mml:math>(<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>) in control. OI increased in the transfused from<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mn>11.7</mml:mn><mml:mo>±</mml:mo><mml:mn>0.9</mml:mn></mml:mrow></mml:math>to<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mrow><mml:mn>18.7</mml:mn><mml:mo>±</mml:mo><mml:mn>1.6</mml:mn></mml:mrow></mml:math>but not in control. Ventilator days in the transfused were<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mrow><mml:mn>15.6</mml:mn><mml:mo>±</mml:mo><mml:mn>1.7</mml:mn></mml:mrow></mml:math>versus<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mrow><mml:mn>9.5</mml:mn><mml:mo>±</mml:mo><mml:mn>0.6</mml:mn></mml:mrow></mml:math>days in control (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>). There was a trend towards higher rates of MODS in transfused patients; 29.4% versus 17.7%, odds ratio 1.92, 95% CI; 0.6–5.6 Fisher exact<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.282</mml:mn></mml:mrow></mml:math>. Conclusion . This study suggests that early transfusions of patients with ALI/ARDS were associated with increased ventilatory needs." @default.
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• W2022778360 date "2012-01-01" @default.
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• W2022778360 title "Respiratory Impairment after Early Red Cell Transfusion in Pediatric Patients with ALI/ARDS" @default.
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