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- W2022779867 abstract "Satellite cells are the resident stem cells of adult skeletal muscle. As with all stem cells, how the choice between self-renewal or differentiation is controlled is central to understanding their function. Here, we have explored the role of β-catenin in determining the fate of myogenic satellite cells. Satellite cells express β-catenin, and expression is maintained as they activate and undergo proliferation. Constitutive retroviral-driven expression of wild-type or stabilised β-catenin results in more satellite cells expressing Pax7 without any MyoD – therefore, adopting the self-renewal pathway, with fewer cells undergoing myogenic differentiation. Similarly, preventing the degradation of endogenous β-catenin by inhibiting GSK3β activity also results in more Pax7-positive–MyoD-negative (Pax7+MyoD–) satellite-cell progeny. Consistent with these observations, downregulation of β-catenin using small interfering RNA (siRNA) reduced the proportion of satellite cells that express Pax7 and augmented myogenic differentiation after mitogen withdrawal. Since a dominant-negative version of β-catenin had the same effect as silencing β-catenin using specific siRNA, β-catenin promotes self-renewal via transcriptional control of target genes. Thus, β-catenin signalling in proliferating satellite cells directs these cells towards the self-renewal pathway and, so, contributes to the maintenance of this stem-cell pool in adult skeletal muscle." @default.
- W2022779867 created "2016-06-24" @default.
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- W2022779867 date "2008-05-01" @default.
- W2022779867 modified "2023-09-23" @default.
- W2022779867 title "β-catenin promotes self-renewal of skeletal-muscle satellite cells" @default.
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- W2022779867 doi "https://doi.org/10.1242/jcs.024885" @default.
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