Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022780131> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2022780131 endingPage "350" @default.
- W2022780131 startingPage "343" @default.
- W2022780131 abstract "Summary Background In patients with steroid‐refractory Crohn's disease, the therapeutic goal is to achieve both rapid remission and maintenance of clinical response. Aim To evaluate the long‐term benefit in patients treated with cyclophosphamide pulse therapy and azathioprine or methotrexate, a combination shown to be effective in a recent pilot study. Methods Sixteen patients with acute steroid‐refractory Crohn's disease participated in a prospective open‐labelled uncontrolled pilot study between December 1998 and June 2003. All had a median number of 4 monthly pulses of intravenous cyclophosphamide (750 mg) and were followed until relapse of the disease. Results Thirteen of 16 patients (81%) achieved remission within 8 weeks after two pulses of cyclophosphamide in combination with azathioprine or methotrexate, with a Crohn's Disease Activity Index decrease from 294 to 111 (median). Remission sustained for 19 months (median, range: 1–45). Moreover, eight patients with pyoderma gangrenosum and erythema nodosum who responded to cyclophosphamide have maintained their remission for up to 30 months. Conclusions In steroid refractory patients with Crohn's disease, cyclophosphamide is highly effective to induce remission. This uncontrolled study indicates that cyclophosphamide‐induced remission is long‐lasting under standard immunosuppressive therapy." @default.
- W2022780131 created "2016-06-24" @default.
- W2022780131 creator A5003741083 @default.
- W2022780131 creator A5031708633 @default.
- W2022780131 creator A5031972677 @default.
- W2022780131 creator A5051676834 @default.
- W2022780131 creator A5078081528 @default.
- W2022780131 date "2006-06-26" @default.
- W2022780131 modified "2023-10-15" @default.
- W2022780131 title "Cyclophosphamide pulse therapy followed by azathioprine or methotrexate induces long-term remission in patients with steroid-refractory Crohn's disease" @default.
- W2022780131 cites W1492874213 @default.
- W2022780131 cites W1515690888 @default.
- W2022780131 cites W1573810982 @default.
- W2022780131 cites W1761355724 @default.
- W2022780131 cites W1966511251 @default.
- W2022780131 cites W1971685694 @default.
- W2022780131 cites W1981581885 @default.
- W2022780131 cites W1981610922 @default.
- W2022780131 cites W1995031695 @default.
- W2022780131 cites W2038535814 @default.
- W2022780131 cites W2049683158 @default.
- W2022780131 cites W2068920227 @default.
- W2022780131 cites W2073208829 @default.
- W2022780131 cites W2098638622 @default.
- W2022780131 cites W2132989741 @default.
- W2022780131 cites W2137698871 @default.
- W2022780131 cites W2154117979 @default.
- W2022780131 cites W2168815834 @default.
- W2022780131 cites W2171341132 @default.
- W2022780131 cites W2321453230 @default.
- W2022780131 cites W2325870812 @default.
- W2022780131 cites W2340424973 @default.
- W2022780131 cites W4245470004 @default.
- W2022780131 cites W4316093125 @default.
- W2022780131 doi "https://doi.org/10.1111/j.1365-2036.2006.02988.x" @default.
- W2022780131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16842461" @default.
- W2022780131 hasPublicationYear "2006" @default.
- W2022780131 type Work @default.
- W2022780131 sameAs 2022780131 @default.
- W2022780131 citedByCount "24" @default.
- W2022780131 countsByYear W20227801312012 @default.
- W2022780131 countsByYear W20227801312014 @default.
- W2022780131 countsByYear W20227801312017 @default.
- W2022780131 countsByYear W20227801312020 @default.
- W2022780131 countsByYear W20227801312021 @default.
- W2022780131 countsByYear W20227801312022 @default.
- W2022780131 crossrefType "journal-article" @default.
- W2022780131 hasAuthorship W2022780131A5003741083 @default.
- W2022780131 hasAuthorship W2022780131A5031708633 @default.
- W2022780131 hasAuthorship W2022780131A5031972677 @default.
- W2022780131 hasAuthorship W2022780131A5051676834 @default.
- W2022780131 hasAuthorship W2022780131A5078081528 @default.
- W2022780131 hasConcept C121332964 @default.
- W2022780131 hasConcept C126322002 @default.
- W2022780131 hasConcept C141071460 @default.
- W2022780131 hasConcept C142424586 @default.
- W2022780131 hasConcept C2776694085 @default.
- W2022780131 hasConcept C2776755627 @default.
- W2022780131 hasConcept C2776760755 @default.
- W2022780131 hasConcept C2779134260 @default.
- W2022780131 hasConcept C2779280984 @default.
- W2022780131 hasConcept C2781059491 @default.
- W2022780131 hasConcept C71924100 @default.
- W2022780131 hasConcept C87355193 @default.
- W2022780131 hasConcept C90924648 @default.
- W2022780131 hasConceptScore W2022780131C121332964 @default.
- W2022780131 hasConceptScore W2022780131C126322002 @default.
- W2022780131 hasConceptScore W2022780131C141071460 @default.
- W2022780131 hasConceptScore W2022780131C142424586 @default.
- W2022780131 hasConceptScore W2022780131C2776694085 @default.
- W2022780131 hasConceptScore W2022780131C2776755627 @default.
- W2022780131 hasConceptScore W2022780131C2776760755 @default.
- W2022780131 hasConceptScore W2022780131C2779134260 @default.
- W2022780131 hasConceptScore W2022780131C2779280984 @default.
- W2022780131 hasConceptScore W2022780131C2781059491 @default.
- W2022780131 hasConceptScore W2022780131C71924100 @default.
- W2022780131 hasConceptScore W2022780131C87355193 @default.
- W2022780131 hasConceptScore W2022780131C90924648 @default.
- W2022780131 hasIssue "2" @default.
- W2022780131 hasLocation W20227801311 @default.
- W2022780131 hasLocation W20227801312 @default.
- W2022780131 hasOpenAccess W2022780131 @default.
- W2022780131 hasPrimaryLocation W20227801311 @default.
- W2022780131 hasRelatedWork W1562459443 @default.
- W2022780131 hasRelatedWork W1973499778 @default.
- W2022780131 hasRelatedWork W2002030263 @default.
- W2022780131 hasRelatedWork W2002409888 @default.
- W2022780131 hasRelatedWork W2036292718 @default.
- W2022780131 hasRelatedWork W2057366572 @default.
- W2022780131 hasRelatedWork W2116744214 @default.
- W2022780131 hasRelatedWork W2422194403 @default.
- W2022780131 hasRelatedWork W4285228488 @default.
- W2022780131 hasRelatedWork W5047642 @default.
- W2022780131 hasVolume "24" @default.
- W2022780131 isParatext "false" @default.
- W2022780131 isRetracted "false" @default.
- W2022780131 magId "2022780131" @default.
- W2022780131 workType "article" @default.