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• W2022784397 abstract "Estrogens influence most of the physiological processes in mammals, including but not limited to reproduction, cognition, behavior, vascular system, metabolism and bone integrity. Given this widespread role for estrogen in human physiology, it is not surprising that estrogen influence the pathophysiology of numerous diseases, including cancer (of the reproductive tract as breast, endometrial but also colorectal, prostate, …), as well as neurodegenerative, inflammatory-immune, cardiovascular and metabolic diseases, and osteoporosis. These actions are mediated by the activation of estrogen receptors (ER) alpha (ERα) and beta (ERβ), which regulate target gene transcription (genomic action) through two independent activation functions (AF)-1 and AF-2, but can also elicit rapid membrane initiated steroid signals (MISS). Targeted ER gene inactivation has shown that although ERβ plays an important role in the central nervous system and in the heart, ERα appears to play a prominent role in most of the other tissues. Pharmacological activation or inhibition of ERα and/or ERβ provides already the basis for many therapeutic interventions, from hormone replacement at menopause to prevention of the recurrence of breast cancer. However, the use of these estrogens or selective estrogen receptors modulators (SERMs) have also induced undesired effects. Thus, an important challenge consists now to uncouple the beneficial actions from other deleterious ones. The in vivo molecular “dissection” of ERα represents both a molecular and integrated approach that already allowed to delineate in mouse the role of the main “subfunctions” of the receptor and that could pave the way to an optimization of the ER modulation." @default.
• W2022784397 created "2016-06-24" @default.
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• W2022784397 date "2013-06-01" @default.
• W2022784397 modified "2023-10-17" @default.
• W2022784397 title "Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo" @default.
• W2022784397 cites W1526191746 @default.
• W2022784397 cites W1571431043 @default.
• W2022784397 cites W1575890610 @default.
• W2022784397 cites W1576412791 @default.
• W2022784397 cites W1586699954 @default.
• W2022784397 cites W1593442063 @default.
• W2022784397 cites W1961026612 @default.
• W2022784397 cites W1971055570 @default.
• W2022784397 cites W1971841422 @default.
• W2022784397 cites W1971960644 @default.
• W2022784397 cites W1978262912 @default.
• W2022784397 cites W1980040001 @default.
• W2022784397 cites W1981355666 @default.
• W2022784397 cites W1982607030 @default.
• W2022784397 cites W1984745009 @default.
• W2022784397 cites W1989954597 @default.
• W2022784397 cites W1990529844 @default.
• W2022784397 cites W1994839764 @default.
• W2022784397 cites W2000410035 @default.
• W2022784397 cites W2000836832 @default.
• W2022784397 cites W2002737481 @default.
• W2022784397 cites W2002972193 @default.
• W2022784397 cites W2003332687 @default.
• W2022784397 cites W2003627629 @default.
• W2022784397 cites W2005831605 @default.
• W2022784397 cites W2006862162 @default.
• W2022784397 cites W2006985579 @default.
• W2022784397 cites W2010401605 @default.
• W2022784397 cites W2014455593 @default.
• W2022784397 cites W2020008126 @default.
• W2022784397 cites W2023866211 @default.
• W2022784397 cites W2024138902 @default.
• W2022784397 cites W2024903228 @default.
• W2022784397 cites W2028549421 @default.
• W2022784397 cites W2030128361 @default.
• W2022784397 cites W2036015130 @default.
• W2022784397 cites W2038208040 @default.
• W2022784397 cites W2039871782 @default.
• W2022784397 cites W2041895008 @default.
• W2022784397 cites W2048371302 @default.
• W2022784397 cites W2052253951 @default.
• W2022784397 cites W2053661133 @default.
• W2022784397 cites W2055903935 @default.
• W2022784397 cites W2059194678 @default.
• W2022784397 cites W2068367174 @default.
• W2022784397 cites W2070645147 @default.
• W2022784397 cites W2076092191 @default.
• W2022784397 cites W2077901864 @default.
• W2022784397 cites W2094212464 @default.
• W2022784397 cites W2101197678 @default.
• W2022784397 cites W2103756247 @default.
• W2022784397 cites W2105846317 @default.
• W2022784397 cites W2110217083 @default.
• W2022784397 cites W2110687233 @default.
• W2022784397 cites W2114868315 @default.
• W2022784397 cites W2120653485 @default.
• W2022784397 cites W2121971175 @default.
• W2022784397 cites W2124164095 @default.
• W2022784397 cites W2124375064 @default.
• W2022784397 cites W2131128339 @default.
• W2022784397 cites W2131610283 @default.
• W2022784397 cites W2132385478 @default.
• W2022784397 cites W2139927416 @default.
• W2022784397 cites W2141269411 @default.
• W2022784397 cites W2141349182 @default.
• W2022784397 cites W2143152245 @default.
• W2022784397 cites W2148032010 @default.
• W2022784397 cites W2148788638 @default.
• W2022784397 cites W2149275727 @default.
• W2022784397 cites W2151982507 @default.
• W2022784397 cites W2159203244 @default.
• W2022784397 cites W2164063330 @default.
• W2022784397 cites W2167327786 @default.
• W2022784397 cites W2167644938 @default.
• W2022784397 cites W2169398990 @default.
• W2022784397 cites W2204303744 @default.
• W2022784397 cites W2263539305 @default.
• W2022784397 cites W2293429217 @default.
• W2022784397 cites W2333702587 @default.
• W2022784397 cites W4242699920 @default.
• W2022784397 cites W4248453414 @default.
• W2022784397 cites W4252406202 @default.
• W2022784397 cites W4252409741 @default.
• W2022784397 cites W4254160203 @default.
• W2022784397 doi "https://doi.org/10.1016/j.steroids.2012.11.011" @default.
• W2022784397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23200732" @default.

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