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• W2022784838 abstract "S-phase cyclin-dependent kinases (CDKs) stimulate replication initiation and accelerate progression through the replication timing program, but it is unknown which CDK substrates are responsible for these effects. CDK phosphorylation of the replication factor TICRR (TopBP1-interacting checkpoint and replication regulator)/TRESLIN is required for DNA replication. We show here that phosphorylated TICRR is limiting for S-phase progression. Overexpression of a TICRR mutant with phosphomimetic mutations at two key CDK-phosphorylated residues (TICRR TESE ) stimulates DNA synthesis and shortens S phase by increasing replication initiation. This effect requires the TICRR region that is necessary for its interaction with MDM two-binding protein. Expression of TICRR TESE does not grossly alter the spatial organization of replication forks in the nucleus but does increase replication clusters and the number of replication forks within each cluster. In contrast to CDK hyperactivation, the acceleration of S-phase progression by TICRR TESE does not induce DNA damage. These results show that CDK can stimulate initiation and compress the replication timing program by phosphorylating a single protein, suggesting a simple mechanism by which S-phase length is controlled." @default.
• W2022784838 created "2016-06-24" @default.
• W2022784838 creator A5016601011 @default.
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• W2022784838 date "2015-03-01" @default.
• W2022784838 modified "2023-10-13" @default.
• W2022784838 title "Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation" @default.
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• W2022784838 doi "https://doi.org/10.1101/gad.246827.114" @default.
• W2022784838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4358407" @default.
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