FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022785346> ?p ?o ?g. }

• W2022785346 endingPage "269" @default.
• W2022785346 startingPage "259" @default.
• W2022785346 abstract "Previously, we reported that growth activation of quiescent 3T3-L1 cells by TPA led to a rapid increase of pro-α2 (I) collagen mRNA and protein, while induction of pro-α2 (I) was not observed in VT-1 cells, a line non-mitogenic in the presence of TPA (26). Here, we further examine the expression of pro-α2 (I) collagen during mitogenic stimulation at the molecular level. In addition to pro-α2 (I) mRNA, TPA treatment increased mRNA production of other collagen family members, pro-α1 (I) and pro-α1 (III) although in reduced amounts relative to pro-α2 (I). In contrast to pro-α2 (I), the mRNA expression profiles of several protooncogenes were regulated in both VT-1 and 3T3-L1 cells. Consistent with increased mRNA levels, TPA treated 3T3-L1 cells produced a matrix abundant in collagen type I protein. In vitro nuclear run-on transcription assays demonstrated a 4-fold increase in pro-α2 (I) mRNA that was maximal within 10 min of TPA treatment. Using a chloramphenicol-acetyl transferase (CAT) assay, we identified a TPA sensitive domain within the promoter of the COL1A2 gene. These results establish COL1A2 as an early growth responsive gene, and that its regulation is PKC dependent. Additionally, the increased expression of protooncogenes and transin during TPA stimulation of non-mitogenic VT-1 cells indicated that the regulation of these genes is independent of PKC, indicating the existence of multiple regulatory mechanisms amongst early response genes." @default.
• W2022785346 created "2016-06-24" @default.
• W2022785346 creator A5008776997 @default.
• W2022785346 creator A5008972555 @default.
• W2022785346 creator A5057857434 @default.
• W2022785346 creator A5059592165 @default.
• W2022785346 date "1996-01-01" @default.
• W2022785346 modified "2023-09-27" @default.
• W2022785346 title "The Phorbol Ester TPA Regulates Collagen Gene Expression at the Transcriptional Level." @default.
• W2022785346 cites W1481283361 @default.
• W2022785346 cites W1498554246 @default.
• W2022785346 cites W1594758412 @default.
• W2022785346 cites W1604033142 @default.
• W2022785346 cites W161204493 @default.
• W2022785346 cites W1760280961 @default.
• W2022785346 cites W1867843855 @default.
• W2022785346 cites W1908718505 @default.
• W2022785346 cites W1916260177 @default.
• W2022785346 cites W1931472297 @default.
• W2022785346 cites W1964839077 @default.
• W2022785346 cites W1967004332 @default.
• W2022785346 cites W1976352707 @default.
• W2022785346 cites W1982174012 @default.
• W2022785346 cites W1982598173 @default.
• W2022785346 cites W1982828360 @default.
• W2022785346 cites W1986309376 @default.
• W2022785346 cites W1988300335 @default.
• W2022785346 cites W1992472345 @default.
• W2022785346 cites W1994323668 @default.
• W2022785346 cites W2000371106 @default.
• W2022785346 cites W2002161597 @default.
• W2022785346 cites W2009295321 @default.
• W2022785346 cites W2009310436 @default.
• W2022785346 cites W2009886925 @default.
• W2022785346 cites W2020672093 @default.
• W2022785346 cites W2022598894 @default.
• W2022785346 cites W2023713083 @default.
• W2022785346 cites W2034225514 @default.
• W2022785346 cites W2036824257 @default.
• W2022785346 cites W2042917826 @default.
• W2022785346 cites W2052977964 @default.
• W2022785346 cites W2053777115 @default.
• W2022785346 cites W2054100350 @default.
• W2022785346 cites W2056744253 @default.
• W2022785346 cites W2060333964 @default.
• W2022785346 cites W2064265012 @default.
• W2022785346 cites W2065150282 @default.
• W2022785346 cites W2067819949 @default.
• W2022785346 cites W2076690965 @default.
• W2022785346 cites W2077475937 @default.
• W2022785346 cites W2079235460 @default.
• W2022785346 cites W2083869788 @default.
• W2022785346 cites W2086524338 @default.
• W2022785346 cites W2092237565 @default.
• W2022785346 cites W2093458878 @default.
• W2022785346 cites W2141453025 @default.
• W2022785346 cites W2411300918 @default.
• W2022785346 cites W2412275578 @default.
• W2022785346 cites W303608415 @default.
• W2022785346 cites W2404517103 @default.
• W2022785346 doi "https://doi.org/10.1247/csf.21.259" @default.
• W2022785346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8906362" @default.
• W2022785346 hasPublicationYear "1996" @default.
• W2022785346 type Work @default.
• W2022785346 sameAs 2022785346 @default.
• W2022785346 citedByCount "2" @default.
• W2022785346 crossrefType "journal-article" @default.
• W2022785346 hasAuthorship W2022785346A5008776997 @default.
• W2022785346 hasAuthorship W2022785346A5008972555 @default.
• W2022785346 hasAuthorship W2022785346A5057857434 @default.
• W2022785346 hasAuthorship W2022785346A5059592165 @default.
• W2022785346 hasBestOaLocation W20227853461 @default.
• W2022785346 hasConcept C104317684 @default.
• W2022785346 hasConcept C105580179 @default.
• W2022785346 hasConcept C138885662 @default.
• W2022785346 hasConcept C150194340 @default.
• W2022785346 hasConcept C153911025 @default.
• W2022785346 hasConcept C179926584 @default.
• W2022785346 hasConcept C195794163 @default.
• W2022785346 hasConcept C41895202 @default.
• W2022785346 hasConcept C55493867 @default.
• W2022785346 hasConcept C62478195 @default.
• W2022785346 hasConcept C86803240 @default.
• W2022785346 hasConcept C95444343 @default.
• W2022785346 hasConceptScore W2022785346C104317684 @default.
• W2022785346 hasConceptScore W2022785346C105580179 @default.
• W2022785346 hasConceptScore W2022785346C138885662 @default.
• W2022785346 hasConceptScore W2022785346C150194340 @default.
• W2022785346 hasConceptScore W2022785346C153911025 @default.
• W2022785346 hasConceptScore W2022785346C179926584 @default.
• W2022785346 hasConceptScore W2022785346C195794163 @default.
• W2022785346 hasConceptScore W2022785346C41895202 @default.
• W2022785346 hasConceptScore W2022785346C55493867 @default.
• W2022785346 hasConceptScore W2022785346C62478195 @default.
• W2022785346 hasConceptScore W2022785346C86803240 @default.
• W2022785346 hasConceptScore W2022785346C95444343 @default.
• W2022785346 hasIssue "4" @default.
• W2022785346 hasLocation W20227853461 @default.

• next