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- W2022785622 abstract "In striated muscle, the Z-band transmits force between contracting sarcomeres; however, it is not merely a static anchor for actin filaments cross-linked by alpha-actinin. Shimamoto observed a coordinated yielding of adjacent sarcomeres in response to stretch, and its disruption by an alpha-actinin antibody [1], indicating an active Z-band function and communication between adjacent sarcomeres. We hypothesized the inter-sarcomeric communication must involve a previously observed but poorly understood, reversible transition between two Z-band structures descriptively called small-square and basketweave [2], implying that alpha-actinin antibody must shift the equilibrium between the two states. Using EM, we imaged Z-bands of chemically-skinned relaxed rabbit soleus fibers and found that alpha-actinin antibody induces complete conversion to the basketweave form of the Z-band, whereas control fibers without antibody show the expected small square form. Since the small-square form was previously associated with relaxed fibers and basketweave with contracted fibers [2], our results suggest that the basketweave Z-band may store elastic energy, which can then favor or drive sarcomere relaxation when the Z-band reverts to the small-square structure. By locking the Z-band in the basketweave form, the antibody prevents the relaxation and concomitant yielding of adjacent sarcomeres previously observed [1]. In parallel mechanics experiments, we found antibody treatment did not interfere with maximal calcium-activated isometric contraction and relaxation; however isometric force and stretch-activation force during sub-maximal activation by ADP were both reduced after antibody treatment. Thus, the alteration of Z-band form by antibody only affects the muscle's dynamic response to stretch during partial activation.1. Shimamoto, Y, et al. Inter-sarcomere coordination in muscle revealed through individual sarcomere response to quick stretch. PNAS, 2009. 106(29):11954-9.2. Goldstein, MA, et al. The Z-band lattice in skeletal muscle before, during and after tetanic contraction. J Muscle Res, 1986. 7(6):527-36." @default.
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- W2022785622 date "2015-01-01" @default.
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- W2022785622 title "An Active Role for the Z-Band during Contraction and Relaxation" @default.
- W2022785622 doi "https://doi.org/10.1016/j.bpj.2014.11.1848" @default.
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