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- W2022787050 abstract "Sera of patients with Graves' disease contain immunoglobulins (IgG) that bind to thyroid plasma membranes, inhibiting thereby the binding of [125I]bovine TSH to its receptors [TSH-binding inhibitory IgG (TBII)], activate adenylate cyclase, or do both. In this report, we describe a new method for the extensive purification of IgG specific to the serum of patients with Graves' disease, using receptor purification as the isolation technique and the TBII assay as an index of activity. Human thyroid tissue was considered an undesirable source of receptor for two reasons. First, the IgG of sera of patients with Graves' disease almost always contain antimicrosomal and/or antithyroglobulin antibodies found in patients with other thyroid diseases, especially Hashimoto's thyroiditis. Second, many preparations of IgG from normal sera display TBII activity, suggesting that normal IgG also bind to human thyroid plasma membranes. Consequently, guinea pig fat cell membranes (FCM), which contain a high affinity receptor ..." @default.
- W2022787050 created "2016-06-24" @default.
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- W2022787050 date "1981-06-01" @default.
- W2022787050 modified "2023-09-23" @default.
- W2022787050 title "Development and Evaluation of a Method for the Partial Purification of Immunoglobulins Specific for Graves’ Disease*" @default.
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- W2022787050 doi "https://doi.org/10.1210/jcem-52-6-1113" @default.
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