Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022787753> ?p ?o ?g. }
- W2022787753 endingPage "e1003811" @default.
- W2022787753 startingPage "e1003811" @default.
- W2022787753 abstract "Pattern formation in developing tissues is driven by the interaction of extrinsic signals with intrinsic transcriptional networks that together establish spatially and temporally restricted profiles of gene expression. How this process is orchestrated at the molecular level by genomic cis-regulatory modules is one of the central questions in developmental biology. Here we have addressed this by analysing the regulation of Pax3 expression in the context of the developing spinal cord. Pax3 is induced early during neural development in progenitors of the dorsal spinal cord and is maintained as pattern is subsequently elaborated, resulting in the segregation of the tissue into dorsal and ventral subdivisions. We used a combination of comparative genomics and transgenic assays to define and dissect several functional cis-regulatory modules associated with the Pax3 locus. We provide evidence that the coordinated activity of two modules establishes and refines Pax3 expression during neural tube development. Mutational analyses of the initiating element revealed that in addition to Wnt signaling, Nkx family homeodomain repressors restrict Pax3 transcription to the presumptive dorsal neural tube. Subsequently, a second module mediates direct positive autoregulation and feedback to maintain Pax3 expression. Together, these data indicate a mechanism by which transient external signals are converted into a sustained expression domain by the activities of distinct regulatory elements. This transcriptional logic differs from the cross-repression that is responsible for the spatiotemporal patterns of gene expression in the ventral neural tube, suggesting that a variety of circuits are deployed within the neural tube regulatory network to establish and elaborate pattern formation." @default.
- W2022787753 created "2016-06-24" @default.
- W2022787753 creator A5019391436 @default.
- W2022787753 creator A5023273450 @default.
- W2022787753 creator A5024730948 @default.
- W2022787753 creator A5052890795 @default.
- W2022787753 creator A5067119495 @default.
- W2022787753 creator A5074144867 @default.
- W2022787753 date "2013-10-03" @default.
- W2022787753 modified "2023-10-16" @default.
- W2022787753 title "Distinct Regulatory Mechanisms Act to Establish and Maintain Pax3 Expression in the Developing Neural Tube" @default.
- W2022787753 cites W110925524 @default.
- W2022787753 cites W1481472040 @default.
- W2022787753 cites W1501165471 @default.
- W2022787753 cites W1504807885 @default.
- W2022787753 cites W1616463521 @default.
- W2022787753 cites W1964478384 @default.
- W2022787753 cites W1967191615 @default.
- W2022787753 cites W1972013835 @default.
- W2022787753 cites W1973483073 @default.
- W2022787753 cites W1974467793 @default.
- W2022787753 cites W1978292443 @default.
- W2022787753 cites W1982087641 @default.
- W2022787753 cites W1983203915 @default.
- W2022787753 cites W1987839415 @default.
- W2022787753 cites W1990633759 @default.
- W2022787753 cites W1993000387 @default.
- W2022787753 cites W1993663161 @default.
- W2022787753 cites W1994881558 @default.
- W2022787753 cites W1999936485 @default.
- W2022787753 cites W2004602258 @default.
- W2022787753 cites W2005318778 @default.
- W2022787753 cites W2006047257 @default.
- W2022787753 cites W2006169062 @default.
- W2022787753 cites W2006824094 @default.
- W2022787753 cites W2006828169 @default.
- W2022787753 cites W2011577522 @default.
- W2022787753 cites W2014479208 @default.
- W2022787753 cites W2014721239 @default.
- W2022787753 cites W2021373833 @default.
- W2022787753 cites W2024471725 @default.
- W2022787753 cites W2026690931 @default.
- W2022787753 cites W2038432212 @default.
- W2022787753 cites W2040773128 @default.
- W2022787753 cites W2044715270 @default.
- W2022787753 cites W2053188090 @default.
- W2022787753 cites W2061425021 @default.
- W2022787753 cites W2066729924 @default.
- W2022787753 cites W2070250500 @default.
- W2022787753 cites W2070314600 @default.
- W2022787753 cites W2071284347 @default.
- W2022787753 cites W2077122170 @default.
- W2022787753 cites W2077154296 @default.
- W2022787753 cites W2080152736 @default.
- W2022787753 cites W2081235375 @default.
- W2022787753 cites W2082807347 @default.
- W2022787753 cites W2090160722 @default.
- W2022787753 cites W2091286015 @default.
- W2022787753 cites W2093339437 @default.
- W2022787753 cites W2103777723 @default.
- W2022787753 cites W2105919528 @default.
- W2022787753 cites W2109204015 @default.
- W2022787753 cites W2121841565 @default.
- W2022787753 cites W2122109009 @default.
- W2022787753 cites W2124809681 @default.
- W2022787753 cites W2126060886 @default.
- W2022787753 cites W2137015675 @default.
- W2022787753 cites W2144274759 @default.
- W2022787753 cites W2149442523 @default.
- W2022787753 cites W2151754128 @default.
- W2022787753 cites W2157009395 @default.
- W2022787753 cites W2157103346 @default.
- W2022787753 cites W2158295165 @default.
- W2022787753 cites W2159902876 @default.
- W2022787753 cites W2160994463 @default.
- W2022787753 cites W2165622092 @default.
- W2022787753 cites W2171181428 @default.
- W2022787753 cites W2186816170 @default.
- W2022787753 cites W2187079233 @default.
- W2022787753 cites W4232123484 @default.
- W2022787753 cites W4243652998 @default.
- W2022787753 cites W4248042899 @default.
- W2022787753 doi "https://doi.org/10.1371/journal.pgen.1003811" @default.
- W2022787753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3789833" @default.
- W2022787753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24098141" @default.
- W2022787753 hasPublicationYear "2013" @default.
- W2022787753 type Work @default.
- W2022787753 sameAs 2022787753 @default.
- W2022787753 citedByCount "27" @default.
- W2022787753 countsByYear W20227877532014 @default.
- W2022787753 countsByYear W20227877532015 @default.
- W2022787753 countsByYear W20227877532016 @default.
- W2022787753 countsByYear W20227877532017 @default.
- W2022787753 countsByYear W20227877532018 @default.
- W2022787753 countsByYear W20227877532019 @default.
- W2022787753 countsByYear W20227877532021 @default.
- W2022787753 countsByYear W20227877532022 @default.
- W2022787753 crossrefType "journal-article" @default.