Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022788768> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2022788768 endingPage "163" @default.
- W2022788768 startingPage "157" @default.
- W2022788768 abstract "The protective effects of the 21-aminosteroid tirilazad mesylate (U-74006F), one of the most efficacious inhibitors of free radical-initiated lipid peroxidation, against ischemic brain damage particularly in permanent focal cerebral ischemia still remain controversial. The present study was designed to determine the degree of neuroprotection produced by various doses of U-74006F in permanent middle cerebral artery occlusion. Focal cerebral ischemia was achieved by permanent occlusion of the left middle cerebral artery in male Sprague-Dawley rats. Four groups of rats were studied: viz. vehicle-administered controls (n = 7), and U-74006F-treated animals at doses of 0.3 mg/kg (n = 7), 1.0 mg/kg (n = 7) and 3.0 mg/kg (n = 7) (i.v. 15 min, 2 h and 6 h post occlusion, and 3.3 times higher than the first 3 doses, i.p. 12 h post occlusion). Twenty-four hours after surgery, the animals were subjected to neurological examination using a grading scale of 0 to 3, and sacrificed to assess ischemic damage by means of tetrazolium chloride staining. A dose-related attenuation of neurological deficits and ischemic damage was observed. At the two highest doses, the volume of ischemic damage in the cerebral hemisphere was reduced by 25.3% (P < 0.05) and 32.9% (P < 0.005), compared to the controls. The neurological deficit score for animals treated with U-74006F (3.0 mg/kg) was also significantly lower than for the controls (1.7 +/- 1.1 vs. 2.7 +/- 0.8; P < 0.05). This study shows that U-74006F ameliorates postischemic neurologic deficits and provides dose-dependent neuroprotection against ischemic brain damage in focal cerebral infarction." @default.
- W2022788768 created "2016-06-24" @default.
- W2022788768 creator A5002997691 @default.
- W2022788768 creator A5047183900 @default.
- W2022788768 date "1994-05-01" @default.
- W2022788768 modified "2023-10-12" @default.
- W2022788768 title "Dose-response analysis of the effect of 21-aminosteroid tirilazad mesylate (U-74006F) upon neurological outcome and ischemic brain damage in permanent focal cerebral ischemia" @default.
- W2022788768 cites W1525126868 @default.
- W2022788768 cites W1527947633 @default.
- W2022788768 cites W1975139578 @default.
- W2022788768 cites W1978910437 @default.
- W2022788768 cites W1980370046 @default.
- W2022788768 cites W1982386154 @default.
- W2022788768 cites W1992850781 @default.
- W2022788768 cites W2003546423 @default.
- W2022788768 cites W2009482377 @default.
- W2022788768 cites W2013813451 @default.
- W2022788768 cites W2028759627 @default.
- W2022788768 cites W2031702150 @default.
- W2022788768 cites W2032827072 @default.
- W2022788768 cites W2040472632 @default.
- W2022788768 cites W2043423869 @default.
- W2022788768 cites W2045835005 @default.
- W2022788768 cites W2046221247 @default.
- W2022788768 cites W2050039091 @default.
- W2022788768 cites W2059498514 @default.
- W2022788768 cites W2065498565 @default.
- W2022788768 cites W2073521129 @default.
- W2022788768 cites W2074114519 @default.
- W2022788768 cites W2077393263 @default.
- W2022788768 cites W2077831615 @default.
- W2022788768 cites W2081272875 @default.
- W2022788768 cites W2083548474 @default.
- W2022788768 cites W2085652502 @default.
- W2022788768 cites W2095450169 @default.
- W2022788768 cites W2098282462 @default.
- W2022788768 cites W2123351961 @default.
- W2022788768 cites W2125683177 @default.
- W2022788768 cites W2136407564 @default.
- W2022788768 cites W2151895572 @default.
- W2022788768 doi "https://doi.org/10.1016/0006-8993(94)91649-7" @default.
- W2022788768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8062078" @default.
- W2022788768 hasPublicationYear "1994" @default.
- W2022788768 type Work @default.
- W2022788768 sameAs 2022788768 @default.
- W2022788768 citedByCount "71" @default.
- W2022788768 countsByYear W20227887682013 @default.
- W2022788768 countsByYear W20227887682014 @default.
- W2022788768 countsByYear W20227887682016 @default.
- W2022788768 countsByYear W20227887682019 @default.
- W2022788768 countsByYear W20227887682020 @default.
- W2022788768 countsByYear W20227887682022 @default.
- W2022788768 countsByYear W20227887682023 @default.
- W2022788768 crossrefType "journal-article" @default.
- W2022788768 hasAuthorship W2022788768A5002997691 @default.
- W2022788768 hasAuthorship W2022788768A5047183900 @default.
- W2022788768 hasConcept C126322002 @default.
- W2022788768 hasConcept C25498285 @default.
- W2022788768 hasConcept C2775841333 @default.
- W2022788768 hasConcept C2776151105 @default.
- W2022788768 hasConcept C2776268601 @default.
- W2022788768 hasConcept C2780829032 @default.
- W2022788768 hasConcept C2781458332 @default.
- W2022788768 hasConcept C42219234 @default.
- W2022788768 hasConcept C541997718 @default.
- W2022788768 hasConcept C71924100 @default.
- W2022788768 hasConcept C98274493 @default.
- W2022788768 hasConceptScore W2022788768C126322002 @default.
- W2022788768 hasConceptScore W2022788768C25498285 @default.
- W2022788768 hasConceptScore W2022788768C2775841333 @default.
- W2022788768 hasConceptScore W2022788768C2776151105 @default.
- W2022788768 hasConceptScore W2022788768C2776268601 @default.
- W2022788768 hasConceptScore W2022788768C2780829032 @default.
- W2022788768 hasConceptScore W2022788768C2781458332 @default.
- W2022788768 hasConceptScore W2022788768C42219234 @default.
- W2022788768 hasConceptScore W2022788768C541997718 @default.
- W2022788768 hasConceptScore W2022788768C71924100 @default.
- W2022788768 hasConceptScore W2022788768C98274493 @default.
- W2022788768 hasIssue "1-2" @default.
- W2022788768 hasLocation W20227887681 @default.
- W2022788768 hasLocation W20227887682 @default.
- W2022788768 hasOpenAccess W2022788768 @default.
- W2022788768 hasPrimaryLocation W20227887681 @default.
- W2022788768 hasRelatedWork W1988725105 @default.
- W2022788768 hasRelatedWork W2034773528 @default.
- W2022788768 hasRelatedWork W2061686604 @default.
- W2022788768 hasRelatedWork W2077655479 @default.
- W2022788768 hasRelatedWork W2095198015 @default.
- W2022788768 hasRelatedWork W2308960466 @default.
- W2022788768 hasRelatedWork W2995727304 @default.
- W2022788768 hasRelatedWork W4295886409 @default.
- W2022788768 hasRelatedWork W1517805603 @default.
- W2022788768 hasRelatedWork W1593223226 @default.
- W2022788768 hasVolume "645" @default.
- W2022788768 isParatext "false" @default.
- W2022788768 isRetracted "false" @default.
- W2022788768 magId "2022788768" @default.
- W2022788768 workType "article" @default.