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• W2022789045 abstract "In Brief Inhibition of the mitochondrial permeability transition pore (mPTP) mediates the protective effects of brief, repetitive ischemic episodes during early reperfusion after prolonged coronary artery occlusion. Brief exposure to isoflurane immediately before and during early reperfusion also produces cardioprotection, but whether mPTP is involved in this beneficial effect is unknown. We tested the hypothesis that mPTP mediates isoflurane-induced postconditioning and also examined the role of mitochondrial KATP (mKATP) channels in this process. Rabbits (n = 102) subjected to a 30-min coronary occlusion followed by 3 h reperfusion received 0.9% saline (control), isoflurane (0.5 or 1.0 MAC) administered for 3 min before and 2 min after reperfusion, or the mPTP inhibitor cyclosporin A (CsA, 5 or 10 mg/kg) in the presence or absence of the mPTP opener atractyloside (5 mg/kg) or the selective mKATP channel antagonist 5-hydroxydecanoate (5-HD; 10 mg/kg). Other rabbits received 0.5 MAC isoflurane plus 5 mg/kg CsA in the presence and absence of atractyloside or 5-HD. Isoflurane (1.0 but not 0.5 MAC) and CsA (10 but not 5 mg/kg) reduced (P < 0.05) infarct size (21% ± 4%, 44% ± 6%, 24% ± 3%, and 43% ± 6%, respectively, mean ± sd of left ventricular area at risk; triphenyltetrazolium staining) as compared with control (42% ± 7%). Isoflurane (0.5 MAC) plus CsA (5 mg/kg) was also protective (27% ± 4%). Neither atractyloside nor 5-HD alone affected infarct size, but these drugs abolished protection by 1.0 MAC isoflurane, 10 mg/kg CsA, and 0.5 MAC isoflurane plus 5 mg/kg CsA. The results indicate that mPTP inhibition enhances, whereas opening abolishes, isoflurane-induced postconditioning. This isoflurane-induced inhibition of mitochondrial permeability transition is dependent on activation of mitochondrial KATP channels in vivo. IMPLICATIONS: Inhibition of the mitochondrial permeability transition pore enhances, whereas opening abolishes, reductions in myocardial infarct size produced by isoflurane when this volatile anesthetic is administered immediately before and during early reperfusion in rabbits. This isoflurane-induced inhibition of mitochondrial permeability transition is dependent on activation of mitochondrial KATP channels." @default.
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• W2022789045 date "2005-12-01" @default.
• W2022789045 modified "2023-10-12" @default.
• W2022789045 title "Inhibition of Mitochondrial Permeability Transition Enhances Isoflurane-Induced Cardioprotection During Early Reperfusion: The Role of Mitochondrial KATP Channels" @default.
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• W2022789045 doi "https://doi.org/10.1213/01.ane.0000181288.13549.28" @default.
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