Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022789691> ?p ?o ?g. }
- W2022789691 endingPage "1315" @default.
- W2022789691 startingPage "1307" @default.
- W2022789691 abstract "The objective of this study was to develop and characterize a biodegradable drug-loaded nerve guide for peripheral nerve regeneration. Sabeluzole, a nerve growth agent, was selected as model compound. Four biodegradable polymers were selected for this study: a copolymer of polylactic acid and polycaprolactone (PCL); a copolymer of polyglycolic acid and polycaprolactone PCL; a copolymer of PCL/polydioxanone (PDO) and PDO. Placebo and drug loaded nerve guides were obtained by melt compression and melt extrusion. It was observed that melt compression and melt extrusion are feasible techniques to prepare the nerve guides. Based on the physicochemical characterization, all samples show absence of crystalline sabeluzole, indicating the formation of an amorphous dispersion. The in vitro release measurements show that the release of sabeluzole is complete, reproducible and can be controlled by the proper selection of the polymer. The release mechanism for all samples follows Fickian release behaviour." @default.
- W2022789691 created "2016-06-24" @default.
- W2022789691 creator A5016140899 @default.
- W2022789691 creator A5018083369 @default.
- W2022789691 creator A5022994000 @default.
- W2022789691 creator A5028922945 @default.
- W2022789691 creator A5030820978 @default.
- W2022789691 creator A5039837606 @default.
- W2022789691 creator A5042947284 @default.
- W2022789691 creator A5044702533 @default.
- W2022789691 creator A5046800597 @default.
- W2022789691 creator A5052108006 @default.
- W2022789691 creator A5063204000 @default.
- W2022789691 creator A5063483168 @default.
- W2022789691 creator A5068046561 @default.
- W2022789691 creator A5078223635 @default.
- W2022789691 creator A5085946732 @default.
- W2022789691 date "2005-04-01" @default.
- W2022789691 modified "2023-10-10" @default.
- W2022789691 title "Preparation and physicochemical characterization of biodegradable nerve guides containing the nerve growth agent sabeluzole" @default.
- W2022789691 cites W1963947696 @default.
- W2022789691 cites W1970892256 @default.
- W2022789691 cites W1974587859 @default.
- W2022789691 cites W1977170360 @default.
- W2022789691 cites W1980697217 @default.
- W2022789691 cites W1987232086 @default.
- W2022789691 cites W1994864223 @default.
- W2022789691 cites W1998884668 @default.
- W2022789691 cites W2001401457 @default.
- W2022789691 cites W2004035928 @default.
- W2022789691 cites W2008235361 @default.
- W2022789691 cites W2013322047 @default.
- W2022789691 cites W2020165673 @default.
- W2022789691 cites W2022909914 @default.
- W2022789691 cites W2023678209 @default.
- W2022789691 cites W2038078632 @default.
- W2022789691 cites W2044027785 @default.
- W2022789691 cites W2044594845 @default.
- W2022789691 cites W2047246701 @default.
- W2022789691 cites W2048903275 @default.
- W2022789691 cites W2058020736 @default.
- W2022789691 cites W2064974242 @default.
- W2022789691 cites W2074959702 @default.
- W2022789691 cites W2075179133 @default.
- W2022789691 cites W2081887314 @default.
- W2022789691 cites W2086130473 @default.
- W2022789691 cites W2087399647 @default.
- W2022789691 cites W2119748429 @default.
- W2022789691 cites W2135907032 @default.
- W2022789691 cites W2142264194 @default.
- W2022789691 cites W2149111315 @default.
- W2022789691 cites W2160243634 @default.
- W2022789691 cites W3738596 @default.
- W2022789691 cites W623363343 @default.
- W2022789691 doi "https://doi.org/10.1016/j.biomaterials.2004.04.040" @default.
- W2022789691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15475061" @default.
- W2022789691 hasPublicationYear "2005" @default.
- W2022789691 type Work @default.
- W2022789691 sameAs 2022789691 @default.
- W2022789691 citedByCount "80" @default.
- W2022789691 countsByYear W20227896912012 @default.
- W2022789691 countsByYear W20227896912013 @default.
- W2022789691 countsByYear W20227896912014 @default.
- W2022789691 countsByYear W20227896912015 @default.
- W2022789691 countsByYear W20227896912016 @default.
- W2022789691 countsByYear W20227896912017 @default.
- W2022789691 countsByYear W20227896912018 @default.
- W2022789691 countsByYear W20227896912019 @default.
- W2022789691 countsByYear W20227896912020 @default.
- W2022789691 countsByYear W20227896912021 @default.
- W2022789691 countsByYear W20227896912022 @default.
- W2022789691 countsByYear W20227896912023 @default.
- W2022789691 crossrefType "journal-article" @default.
- W2022789691 hasAuthorship W2022789691A5016140899 @default.
- W2022789691 hasAuthorship W2022789691A5018083369 @default.
- W2022789691 hasAuthorship W2022789691A5022994000 @default.
- W2022789691 hasAuthorship W2022789691A5028922945 @default.
- W2022789691 hasAuthorship W2022789691A5030820978 @default.
- W2022789691 hasAuthorship W2022789691A5039837606 @default.
- W2022789691 hasAuthorship W2022789691A5042947284 @default.
- W2022789691 hasAuthorship W2022789691A5044702533 @default.
- W2022789691 hasAuthorship W2022789691A5046800597 @default.
- W2022789691 hasAuthorship W2022789691A5052108006 @default.
- W2022789691 hasAuthorship W2022789691A5063204000 @default.
- W2022789691 hasAuthorship W2022789691A5063483168 @default.
- W2022789691 hasAuthorship W2022789691A5068046561 @default.
- W2022789691 hasAuthorship W2022789691A5078223635 @default.
- W2022789691 hasAuthorship W2022789691A5085946732 @default.
- W2022789691 hasConcept C127413603 @default.
- W2022789691 hasConcept C136229726 @default.
- W2022789691 hasConcept C15920480 @default.
- W2022789691 hasConcept C159985019 @default.
- W2022789691 hasConcept C192562407 @default.
- W2022789691 hasConcept C2778958987 @default.
- W2022789691 hasConcept C2779868350 @default.
- W2022789691 hasConcept C2781162966 @default.
- W2022789691 hasConcept C42360764 @default.
- W2022789691 hasConcept C45211672 @default.