FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022790215> ?p ?o ?g. }

• W2022790215 endingPage "1449" @default.
• W2022790215 startingPage "1441" @default.
• W2022790215 abstract "Successful gene therapy for most inherited diseases will require stable expression of the therapeutic gene. This can be addressed with integrating or self-replicating viruses by targeting postmitotic cells that have a long lifetime or stem cells that can replenish defective tissue with corrected cells. In this study, we explore the possibility of targeting a muscle stem cell population in situ through in vivo administration of vector. To develop this concept, we selected a mouse model of muscular dystrophy (mdx mice) that undergoes rapid turnover of muscle fibers. In vivo targeting of muscle progenitor cells, notably satellite cells, with a pseudotyped lentiviral vector encoding the minidystrophin restores dystrophin expression and provides functional correction in skeletal muscle of mdx mice. This study shows that progenitor cells can be genetically engineered in vivo and subsequently proliferate into terminally differentiated tissue carrying the genetic graft in a way that stably corrects function." @default.
• W2022790215 created "2016-06-24" @default.
• W2022790215 creator A5002499186 @default.
• W2022790215 creator A5006292602 @default.
• W2022790215 creator A5042468162 @default.
• W2022790215 creator A5051344823 @default.
• W2022790215 creator A5051652706 @default.
• W2022790215 date "2003-10-10" @default.
• W2022790215 modified "2023-09-23" @default.
• W2022790215 title "Correction of the Dystrophic Phenotype by<i>In Vivo</i>Targeting of Muscle Progenitor Cells" @default.
• W2022790215 cites W1485992471 @default.
• W2022790215 cites W1566969252 @default.
• W2022790215 cites W1966530677 @default.
• W2022790215 cites W1980325503 @default.
• W2022790215 cites W1983852123 @default.
• W2022790215 cites W1985942883 @default.
• W2022790215 cites W1990561446 @default.
• W2022790215 cites W2003335806 @default.
• W2022790215 cites W2009761723 @default.
• W2022790215 cites W2018483078 @default.
• W2022790215 cites W2032097547 @default.
• W2022790215 cites W2035499535 @default.
• W2022790215 cites W2047015778 @default.
• W2022790215 cites W2060489599 @default.
• W2022790215 cites W2072088562 @default.
• W2022790215 cites W2079555292 @default.
• W2022790215 cites W2082305141 @default.
• W2022790215 cites W2097231877 @default.
• W2022790215 cites W2122432632 @default.
• W2022790215 cites W2124026319 @default.
• W2022790215 cites W2139865704 @default.
• W2022790215 cites W2284208499 @default.
• W2022790215 cites W2324521397 @default.
• W2022790215 cites W259784655 @default.
• W2022790215 doi "https://doi.org/10.1089/104303403769211655" @default.
• W2022790215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14577924" @default.
• W2022790215 hasPublicationYear "2003" @default.
• W2022790215 type Work @default.
• W2022790215 sameAs 2022790215 @default.
• W2022790215 citedByCount "55" @default.
• W2022790215 countsByYear W20227902152012 @default.
• W2022790215 countsByYear W20227902152013 @default.
• W2022790215 countsByYear W20227902152015 @default.
• W2022790215 countsByYear W20227902152016 @default.
• W2022790215 countsByYear W20227902152017 @default.
• W2022790215 countsByYear W20227902152022 @default.
• W2022790215 countsByYear W20227902152023 @default.
• W2022790215 crossrefType "journal-article" @default.
• W2022790215 hasAuthorship W2022790215A5002499186 @default.
• W2022790215 hasAuthorship W2022790215A5006292602 @default.
• W2022790215 hasAuthorship W2022790215A5042468162 @default.
• W2022790215 hasAuthorship W2022790215A5051344823 @default.
• W2022790215 hasAuthorship W2022790215A5051652706 @default.
• W2022790215 hasConcept C104317684 @default.
• W2022790215 hasConcept C105702510 @default.
• W2022790215 hasConcept C111599444 @default.
• W2022790215 hasConcept C127716648 @default.
• W2022790215 hasConcept C201750760 @default.
• W2022790215 hasConcept C207001950 @default.
• W2022790215 hasConcept C2778943923 @default.
• W2022790215 hasConcept C2779030066 @default.
• W2022790215 hasConcept C2779959927 @default.
• W2022790215 hasConcept C2780394045 @default.
• W2022790215 hasConcept C28328180 @default.
• W2022790215 hasConcept C2908647359 @default.
• W2022790215 hasConcept C32470452 @default.
• W2022790215 hasConcept C40767141 @default.
• W2022790215 hasConcept C54355233 @default.
• W2022790215 hasConcept C71924100 @default.
• W2022790215 hasConcept C86803240 @default.
• W2022790215 hasConcept C95444343 @default.
• W2022790215 hasConcept C99454951 @default.
• W2022790215 hasConceptScore W2022790215C104317684 @default.
• W2022790215 hasConceptScore W2022790215C105702510 @default.
• W2022790215 hasConceptScore W2022790215C111599444 @default.
• W2022790215 hasConceptScore W2022790215C127716648 @default.
• W2022790215 hasConceptScore W2022790215C201750760 @default.
• W2022790215 hasConceptScore W2022790215C207001950 @default.
• W2022790215 hasConceptScore W2022790215C2778943923 @default.
• W2022790215 hasConceptScore W2022790215C2779030066 @default.
• W2022790215 hasConceptScore W2022790215C2779959927 @default.
• W2022790215 hasConceptScore W2022790215C2780394045 @default.
• W2022790215 hasConceptScore W2022790215C28328180 @default.
• W2022790215 hasConceptScore W2022790215C2908647359 @default.
• W2022790215 hasConceptScore W2022790215C32470452 @default.
• W2022790215 hasConceptScore W2022790215C40767141 @default.
• W2022790215 hasConceptScore W2022790215C54355233 @default.
• W2022790215 hasConceptScore W2022790215C71924100 @default.
• W2022790215 hasConceptScore W2022790215C86803240 @default.
• W2022790215 hasConceptScore W2022790215C95444343 @default.
• W2022790215 hasConceptScore W2022790215C99454951 @default.
• W2022790215 hasIssue "15" @default.
• W2022790215 hasLocation W20227902151 @default.
• W2022790215 hasLocation W20227902152 @default.
• W2022790215 hasOpenAccess W2022790215 @default.
• W2022790215 hasPrimaryLocation W20227902151 @default.
• W2022790215 hasRelatedWork W1991669378 @default.
• W2022790215 hasRelatedWork W2034387481 @default.

• next