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• W2022790874 abstract "In their study, Ueshima et al ( 1 Ueshima E. Yamaguchi M. Ueha T. et al. Inhibition of growth in a rabbit VX2 thigh tumor model with intraarterial infusion of carbon dioxide–saturated solution. J Vasc Interv Radiol. 2014; 25: 469-476 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar ) have demonstrated that infusion of CO2-saturated solution, at least in the short term (3 days), resulted in growth inhibition in a rabbit thigh VX2 tumor model by activation of apoptotic cell death through cleaved caspase-3 upregulation ( 1 Ueshima E. Yamaguchi M. Ueha T. et al. Inhibition of growth in a rabbit VX2 thigh tumor model with intraarterial infusion of carbon dioxide–saturated solution. J Vasc Interv Radiol. 2014; 25: 469-476 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar ). The following three mechanisms are suggested to explain their results: (i) mitochondrial DNA apoptosis induced via intrinsic pathways by increasing intracellular Ca2+ and reactive oxygen species, (ii) an increase in intracellular acidity, and (iii) a stronger Bohr effect (ie, increase in partial pressure of CO2 or lower pH will cause offloading of oxygen from hemoglobin, which allows transport of oxygen to tissues), resulting in improvement of cellular hypoxia in the tumor ( 1 Ueshima E. Yamaguchi M. Ueha T. et al. Inhibition of growth in a rabbit VX2 thigh tumor model with intraarterial infusion of carbon dioxide–saturated solution. J Vasc Interv Radiol. 2014; 25: 469-476 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar ). Inhibition of Growth in a Rabbit VX2 Thigh Tumor Model with Intraarterial Infusion of Carbon Dioxide–Saturated SolutionJournal of Vascular and Interventional RadiologyVol. 25Issue 3PreviewTo evaluate the efficacy of intraarterial infusion of CO2-saturated solution in rabbit VX2 thigh tumors. Full-Text PDF" @default.
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• W2022790874 date "2014-03-01" @default.
• W2022790874 modified "2023-10-18" @default.
• W2022790874 title "CO2 to Live and to Die" @default.
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• W2022790874 doi "https://doi.org/10.1016/j.jvir.2013.12.006" @default.
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