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- W2022791619 abstract "Abstract Chronic bronchitis is a condition in which there is an increase in the bronchial mucous gland volume with resultant hypersecretion of mucus. Infection is a secondary phenomenon. Airways obstruction occurs as a result of (1) exudate in the lumen of the small bronchi and bronchioles, (2) high viscosity of the exudate, (3) interference with mucosal ciliary action, and (4) peribronchiolar fibrosis. Cigarette smoking is an important factor in the etiology of hypersecretory states. Emphysema comprises a group of diseases in which there is a permanent increase in size of that portion of the lung distal to the terminal bronchiole accompanied by destructive changes. The two most important entities are (1) centrilobular emphysema occurring predominantly in males and characterized by dilatation and destruction of the respiratory bronchioles, a predilection of the disease for the upper zones of the lungs and close association with cigarette smoking, and (2) panacinar destructive emphysema occurring in males and females equally and affecting predominantly the lower zones of the lung. Chronic bronchitis is not usually present. The disease may be familial and associated with alpha 1 antitrypsin deficiency. Other forms of emphysema may be due to abnormal lung growth or associated with pulmonary fibrosis. Airways obstruction when present in emphysema is associated with bronchiolar plugging by exudate and peribronchiolar fibrosis. These two processes contribute to the alveolar hypoventilation which may result in cor pulmonale." @default.
- W2022791619 created "2016-06-24" @default.
- W2022791619 creator A5080264064 @default.
- W2022791619 date "1974-09-01" @default.
- W2022791619 modified "2023-09-25" @default.
- W2022791619 title "The contribution of morphology to the study of chronic obstructive lung disease" @default.
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