FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022792152> ?p ?o ?g. }

• W2022792152 endingPage "46" @default.
• W2022792152 startingPage "38" @default.
• W2022792152 abstract "A conventional, cholesterol-containing liposome formulation of cisplatin has demonstrated insignificant activity in clinical trials, due in part, to insufficient release of encapsulated content following localization within solid tumors. For this reason, the development of a triggered release liposome formulation is desirable. In this report, cisplatin was encapsulated into lysolipid-containing thermosensitive liposomes (LTSL) using a novel technique, which relies on the equilibration of cisplatin across the liposomal membrane at temperatures above the gel-to-liquid crystalline phase transition temperature (TC) of the bulk phospholipid. Mild heating and drug loading into LTSL did not induce morphological changes of the liposomes. In vitro data demonstrated that >95% of encapsulated cisplatin was released from LTSL within 5 min following mild heating at 42 degrees C, while <5% was released at 37 degrees C. Under similar conditions, lysolipid-free thermosensitive liposomes exhibited 70% release of cisplatin at 42 degrees C, and cholesterol-containing liposomes exhibited negligible drug release at 42 degrees C. The pharmacokinetic profiles of LTSL- and TSL-cisplatin indicated that these formulations were rapidly eliminated from circulation (terminal t(1/2) of 1.09 and 2.83 h, respectively). The therapeutic utility of LTSL-cisplatin formulation will be based on strategies where hyperthermia is applied prior to the administration of the liposomal drug-a strategy similar to that used in the clinical assessment of LTSL-doxorubicin formulation." @default.
• W2022792152 created "2016-06-24" @default.
• W2022792152 creator A5010810577 @default.
• W2022792152 creator A5015373993 @default.
• W2022792152 creator A5021716523 @default.
• W2022792152 creator A5070792731 @default.
• W2022792152 creator A5072060561 @default.
• W2022792152 creator A5073912271 @default.
• W2022792152 creator A5088916202 @default.
• W2022792152 date "2008-02-12" @default.
• W2022792152 modified "2023-09-25" @default.
• W2022792152 title "Use of a passive equilibration methodology to encapsulate cisplatin into preformed thermosensitive liposomes" @default.
• W2022792152 cites W1946720377 @default.
• W2022792152 cites W1966356417 @default.
• W2022792152 cites W1983316742 @default.
• W2022792152 cites W1988607076 @default.
• W2022792152 cites W1992803165 @default.
• W2022792152 cites W1998886157 @default.
• W2022792152 cites W1999841301 @default.
• W2022792152 cites W2002516695 @default.
• W2022792152 cites W2005144734 @default.
• W2022792152 cites W2008640205 @default.
• W2022792152 cites W2012182421 @default.
• W2022792152 cites W2013470095 @default.
• W2022792152 cites W2014109658 @default.
• W2022792152 cites W2015257039 @default.
• W2022792152 cites W2015626183 @default.
• W2022792152 cites W2025470299 @default.
• W2022792152 cites W2026073350 @default.
• W2022792152 cites W2040150720 @default.
• W2022792152 cites W2047421804 @default.
• W2022792152 cites W2060298746 @default.
• W2022792152 cites W2072664731 @default.
• W2022792152 cites W2078909289 @default.
• W2022792152 cites W2099374439 @default.
• W2022792152 cites W2102741391 @default.
• W2022792152 cites W2108677865 @default.
• W2022792152 cites W2111220039 @default.
• W2022792152 cites W2113614699 @default.
• W2022792152 cites W2121945369 @default.
• W2022792152 cites W2126662679 @default.
• W2022792152 cites W2128512834 @default.
• W2022792152 cites W2134660444 @default.
• W2022792152 cites W2164196153 @default.
• W2022792152 cites W2164563042 @default.
• W2022792152 cites W2167144064 @default.
• W2022792152 cites W2170314391 @default.
• W2022792152 cites W2185469212 @default.
• W2022792152 cites W2213954051 @default.
• W2022792152 doi "https://doi.org/10.1016/j.ijpharm.2007.07.020" @default.
• W2022792152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17728083" @default.
• W2022792152 hasPublicationYear "2008" @default.
• W2022792152 type Work @default.
• W2022792152 sameAs 2022792152 @default.
• W2022792152 citedByCount "56" @default.
• W2022792152 countsByYear W20227921522012 @default.
• W2022792152 countsByYear W20227921522013 @default.
• W2022792152 countsByYear W20227921522014 @default.
• W2022792152 countsByYear W20227921522015 @default.
• W2022792152 countsByYear W20227921522016 @default.
• W2022792152 countsByYear W20227921522017 @default.
• W2022792152 countsByYear W20227921522018 @default.
• W2022792152 countsByYear W20227921522020 @default.
• W2022792152 countsByYear W20227921522021 @default.
• W2022792152 crossrefType "journal-article" @default.
• W2022792152 hasAuthorship W2022792152A5010810577 @default.
• W2022792152 hasAuthorship W2022792152A5015373993 @default.
• W2022792152 hasAuthorship W2022792152A5021716523 @default.
• W2022792152 hasAuthorship W2022792152A5070792731 @default.
• W2022792152 hasAuthorship W2022792152A5072060561 @default.
• W2022792152 hasAuthorship W2022792152A5073912271 @default.
• W2022792152 hasAuthorship W2022792152A5088916202 @default.
• W2022792152 hasConcept C112705442 @default.
• W2022792152 hasConcept C12554922 @default.
• W2022792152 hasConcept C126322002 @default.
• W2022792152 hasConcept C13245373 @default.
• W2022792152 hasConcept C185154212 @default.
• W2022792152 hasConcept C185592680 @default.
• W2022792152 hasConcept C2776694085 @default.
• W2022792152 hasConcept C2778239845 @default.
• W2022792152 hasConcept C2778918659 @default.
• W2022792152 hasConcept C2779949491 @default.
• W2022792152 hasConcept C2780035454 @default.
• W2022792152 hasConcept C2781303535 @default.
• W2022792152 hasConcept C41625074 @default.
• W2022792152 hasConcept C43617362 @default.
• W2022792152 hasConcept C55493867 @default.
• W2022792152 hasConcept C71924100 @default.
• W2022792152 hasConcept C86803240 @default.
• W2022792152 hasConcept C98274493 @default.
• W2022792152 hasConceptScore W2022792152C112705442 @default.
• W2022792152 hasConceptScore W2022792152C12554922 @default.
• W2022792152 hasConceptScore W2022792152C126322002 @default.
• W2022792152 hasConceptScore W2022792152C13245373 @default.
• W2022792152 hasConceptScore W2022792152C185154212 @default.
• W2022792152 hasConceptScore W2022792152C185592680 @default.
• W2022792152 hasConceptScore W2022792152C2776694085 @default.
• W2022792152 hasConceptScore W2022792152C2778239845 @default.

• next