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• W2022792593 abstract "<i>Streptococcus mutans</i> is considered the primary etiologic agent of dental caries and contributes significantly to the virulence of dental plaque, especially in the presence of sucrose. To avoid the role of sucrose on the virulence factors of <i>S. mutans</i>, sugar substitutes are commonly consumed because they lead to lower or no production of acids and interfere with biofilm formation. This study aimed to investigate the contribution of sugar substitutes in the cariogenic potential of <i>S. mutans</i> biofilms. Thus, in the presence of sucrose, glucose, sucralose and sorbitol, the biofilm mass was quantified up to 96 h, the pH of the spent culture media was measured, the expression of biofilm-related genes was determined, and demineralization challenge experiments were conduct in enamel fragments. The presence of sugars or sugar substitutes profoundly affected the expression of <i>spaP</i>, <i>gtfB</i>, <i>gtfC</i>, <i>gbpB</i>, <i>ftf</i>, <i>vicR</i> and <i>vicX</i> in either biofilm or planktonic cells. The substitution of sucrose induced a down-regulation of most genes involved in sucrose-dependent colonization in biofilm cells. When the ratio between the expression of biofilm and planktonic cells was considered, most of those genes were down-regulated in biofilm cells in the presence of sugars and up-regulated in the presence of sugar substitutes. However, sucralose but not sorbitol fulfilled the purpose of reducing the cariogenic potential of the diet since it induced the biofilm formation with the lowest biomass, did not change the pH of the medium and led to the lowest lesion depth in the cariogenic challenge." @default.
• W2022792593 created "2016-06-24" @default.
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• W2022792593 date "2014-01-01" @default.
• W2022792593 modified "2023-10-17" @default.
• W2022792593 title "Sucrose Substitutes Affect the Cariogenic Potential of <b><i>Streptococcus mutans</i></b> Biofilms" @default.
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• W2022792593 doi "https://doi.org/10.1159/000354410" @default.
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