FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022792766> ?p ?o ?g. }

• W2022792766 endingPage "32638" @default.
• W2022792766 startingPage "32628" @default.
• W2022792766 abstract "Copper is an essential trace element involved in plenty of redox reactions in living systems, however, unbound copper ions cause damage to various biomolecules via excessive generation of reactive oxygen species. Flavonoids, ubiquitous plant secondary metabolites, possess complex effects on human health and chelation of transient metal ions is one of their proposed mechanisms of action. In this in vitro study, 26 flavonoids from various subclasses were screened for their interactions with both copper oxidation states at four (patho)physiologically relevant pH conditions (4.5, 5.5, 6.8 and 7.5) by two spectrophotometric approaches and compared with the clinically used copper chelator trientine. In a slightly competitive environment, the majority of flavonoids were able to chelate cupric ions, however, under more competitive conditions, only flavones and flavonols were able to chelate both cupric and cuprous ions. Apparently, the 2,3-double bond was essential for stable copper chelation. The most efficient copper chelation sites were the 3-hydroxy-4-keto group in flavonols and the 5,6,7-trihydroxyl group in flavones. On the other hand, the 3′,4′-dihydroxyl group was associated only with a weak activity. 3-Hydroxyflavone, kaempferol and partly baicalein were even more potent than trientine in the acidic environment, however, none of the tested flavonoids was able to surpass it at physiological pH or slightly acidic conditions. In conclusion, flavonoids possessing appropriate structural characteristics were efficient copper chelators and some of them were even more potent than trientine under acidic conditions." @default.
• W2022792766 created "2016-06-24" @default.
• W2022792766 creator A5003219498 @default.
• W2022792766 creator A5020959791 @default.
• W2022792766 creator A5022352437 @default.
• W2022792766 creator A5025402119 @default.
• W2022792766 creator A5029120071 @default.
• W2022792766 creator A5040675645 @default.
• W2022792766 creator A5065222117 @default.
• W2022792766 creator A5069249565 @default.
• W2022792766 creator A5071346689 @default.
• W2022792766 creator A5075845989 @default.
• W2022792766 creator A5079646625 @default.
• W2022792766 date "2014-07-17" @default.
• W2022792766 modified "2023-10-17" @default.
• W2022792766 title "In vitro evaluation of copper-chelating properties of flavonoids" @default.
• W2022792766 cites W1963698191 @default.
• W2022792766 cites W1966521314 @default.
• W2022792766 cites W1973192567 @default.
• W2022792766 cites W1974080012 @default.
• W2022792766 cites W1981753435 @default.
• W2022792766 cites W1982132572 @default.
• W2022792766 cites W1984739331 @default.
• W2022792766 cites W1985498851 @default.
• W2022792766 cites W1988284899 @default.
• W2022792766 cites W1995778942 @default.
• W2022792766 cites W2001504809 @default.
• W2022792766 cites W2001946936 @default.
• W2022792766 cites W2003410494 @default.
• W2022792766 cites W2011336591 @default.
• W2022792766 cites W2022691951 @default.
• W2022792766 cites W2028269667 @default.
• W2022792766 cites W2034739721 @default.
• W2022792766 cites W2047734064 @default.
• W2022792766 cites W2050691003 @default.
• W2022792766 cites W2059103217 @default.
• W2022792766 cites W2064281173 @default.
• W2022792766 cites W2073057315 @default.
• W2022792766 cites W2073560762 @default.
• W2022792766 cites W2075248806 @default.
• W2022792766 cites W2081688458 @default.
• W2022792766 cites W2086959952 @default.
• W2022792766 cites W2087195503 @default.
• W2022792766 cites W2101902354 @default.
• W2022792766 cites W2115824887 @default.
• W2022792766 cites W2117934439 @default.
• W2022792766 cites W2119763722 @default.
• W2022792766 cites W2120228115 @default.
• W2022792766 cites W2121232830 @default.
• W2022792766 cites W2138233204 @default.
• W2022792766 cites W2138310386 @default.
• W2022792766 cites W2139243915 @default.
• W2022792766 cites W2140386182 @default.
• W2022792766 cites W2143190548 @default.
• W2022792766 cites W2144483204 @default.
• W2022792766 cites W2168556140 @default.
• W2022792766 cites W2233474005 @default.
• W2022792766 cites W250778267 @default.
• W2022792766 cites W4236082038 @default.
• W2022792766 doi "https://doi.org/10.1039/c4ra04575k" @default.
• W2022792766 hasPublicationYear "2014" @default.
• W2022792766 type Work @default.
• W2022792766 sameAs 2022792766 @default.
• W2022792766 citedByCount "67" @default.
• W2022792766 countsByYear W20227927662015 @default.
• W2022792766 countsByYear W20227927662016 @default.
• W2022792766 countsByYear W20227927662017 @default.
• W2022792766 countsByYear W20227927662018 @default.
• W2022792766 countsByYear W20227927662019 @default.
• W2022792766 countsByYear W20227927662020 @default.
• W2022792766 countsByYear W20227927662021 @default.
• W2022792766 countsByYear W20227927662022 @default.
• W2022792766 countsByYear W20227927662023 @default.
• W2022792766 crossrefType "journal-article" @default.
• W2022792766 hasAuthorship W2022792766A5003219498 @default.
• W2022792766 hasAuthorship W2022792766A5020959791 @default.
• W2022792766 hasAuthorship W2022792766A5022352437 @default.
• W2022792766 hasAuthorship W2022792766A5025402119 @default.
• W2022792766 hasAuthorship W2022792766A5029120071 @default.
• W2022792766 hasAuthorship W2022792766A5040675645 @default.
• W2022792766 hasAuthorship W2022792766A5065222117 @default.
• W2022792766 hasAuthorship W2022792766A5069249565 @default.
• W2022792766 hasAuthorship W2022792766A5071346689 @default.
• W2022792766 hasAuthorship W2022792766A5075845989 @default.
• W2022792766 hasAuthorship W2022792766A5079646625 @default.
• W2022792766 hasBestOaLocation W20227927661 @default.
• W2022792766 hasConcept C13965031 @default.
• W2022792766 hasConcept C178790620 @default.
• W2022792766 hasConcept C179104552 @default.
• W2022792766 hasConcept C185592680 @default.
• W2022792766 hasConcept C197404232 @default.
• W2022792766 hasConcept C199164860 @default.
• W2022792766 hasConcept C2776292868 @default.
• W2022792766 hasConcept C2778004101 @default.
• W2022792766 hasConcept C2779054382 @default.
• W2022792766 hasConcept C2779106036 @default.
• W2022792766 hasConcept C43617362 @default.
• W2022792766 hasConcept C544153396 @default.

• next