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• W2022792858 abstract "Recent studies of the electrophysiology of cardiac muscle and in particular the fibers of the specialized tissues of the heart have provided information on several physiologic mechanisms which can be responsible for the production of disturbances of rhythm and conduction. Intrinsic rhythmicity is a property of all of the specialized fibers; in some, slow diastolic depolarization is always present, and thus these fibers are latent pacemakers which can and will generate ectopic activity at any time that the frequency of the normal pacemaker is depressed or at any time that their own intrinsic frequency is enchanced. Other fibers may show little evidence of intrinsic rhythmicity under normal conditions but, when influenced by a wide variety of factors (hypoxia, sympathetic activity, stretch, local changes in concentration of K, Ca++, pH and others) will develop rapid pacemaker activity. In addition to the property of intrinsic rhythmicity which is present in the specialized fibers, the differences in action potential duration and conduction velocity of these same cells enhances the likelihood of complex arrhythmias. Studies of single fibers must now be supplemented by records from the specialized conducting system of the intact heart during the clinically important arrhythmias to determine the exact manner in which each disturbance of rate and rhythm is brought about." @default.
• W2022792858 created "2016-06-24" @default.
• W2022792858 creator A5038976168 @default.
• W2022792858 date "1960-01-01" @default.
• W2022792858 modified "2023-09-23" @default.
• W2022792858 title "Physiologic basis of disturbances of cardiac rhythm and conduction" @default.
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• W2022792858 doi "https://doi.org/10.1016/s0033-0620(60)80068-0" @default.
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