Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022793864> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2022793864 endingPage "119" @default.
- W2022793864 startingPage "112" @default.
- W2022793864 abstract "Trypanosoma cruzi Tc13 antigens belong to the trans-sialidase superfamily. Their sequences have been described only partially and, up to now, their physiological activity has not been elucidated. Here we present two new members of this family from the Tulahuén strain (Tc13 Tul) and the CL Brener clone (Tc13 CL), being the latter the first Tc13 sequence fully described. Alignment of all Tc13 sequences allowed us to define two sub-families that differ in the number of repeats and the presence or absence of the GPI addition site. Chromoblots demonstrate that Tc13 antigens are mainly located in chromosome III and its homologous. Pull down assays suggest that recombinant MBP-Tc13 Tul interacts with the second extracellular loop of the β1-adrenergic receptor. This is the first evidence that a Tc13 antigen acts as a ligand interacting with a neurotransmitter receptor. These observations might add some light to the development of chagasic pathology. Index Descriptors and Abbreviations: β1-AR, β1-adrenergic receptor; β1e2, β1-AR second extracellular loop; GPI, glycosylphosphatidyl inositol; GSH, glutathione; GST, glutathione-S-transferase; m2 mAChR, m2 muscarinic cholinergic receptor; m2e2, m2 mAChR second extracellular loop; MBP, maltose binding protein; SjGST, Schistosoma japonicum GST; Tc13 CL, Tc13 antigen from CL Brener clone; Tc13 Tul, Tc13 antigen from Tulahuén strain" @default.
- W2022793864 created "2016-06-24" @default.
- W2022793864 creator A5002091038 @default.
- W2022793864 creator A5024369108 @default.
- W2022793864 creator A5054784713 @default.
- W2022793864 creator A5067621395 @default.
- W2022793864 creator A5083780796 @default.
- W2022793864 creator A5091408096 @default.
- W2022793864 date "2003-03-01" @default.
- W2022793864 modified "2023-10-14" @default.
- W2022793864 title "Trypanosoma cruzi: Molecular identification and characterization of new members of the Tc13 family. Description of the interaction between the Tc13 antigen from Tulahuén strain and the second extracellular loop of the β1-adrenergic receptor" @default.
- W2022793864 cites W1515978161 @default.
- W2022793864 cites W1968683690 @default.
- W2022793864 cites W1971932668 @default.
- W2022793864 cites W1982364815 @default.
- W2022793864 cites W1995277355 @default.
- W2022793864 cites W2034291802 @default.
- W2022793864 cites W2042422987 @default.
- W2022793864 cites W2054893021 @default.
- W2022793864 cites W2055043387 @default.
- W2022793864 cites W2057327068 @default.
- W2022793864 cites W2061182865 @default.
- W2022793864 cites W2063362161 @default.
- W2022793864 cites W2069136265 @default.
- W2022793864 cites W2078447977 @default.
- W2022793864 cites W2091167028 @default.
- W2022793864 cites W2094509346 @default.
- W2022793864 cites W2115372664 @default.
- W2022793864 cites W2116153018 @default.
- W2022793864 cites W2136711098 @default.
- W2022793864 cites W2143044390 @default.
- W2022793864 cites W2158907014 @default.
- W2022793864 cites W2161594864 @default.
- W2022793864 cites W2171091522 @default.
- W2022793864 cites W2186163542 @default.
- W2022793864 cites W842237599 @default.
- W2022793864 doi "https://doi.org/10.1016/s0014-4894(03)00087-0" @default.
- W2022793864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12880587" @default.
- W2022793864 hasPublicationYear "2003" @default.
- W2022793864 type Work @default.
- W2022793864 sameAs 2022793864 @default.
- W2022793864 citedByCount "13" @default.
- W2022793864 countsByYear W20227938642012 @default.
- W2022793864 countsByYear W20227938642013 @default.
- W2022793864 countsByYear W20227938642016 @default.
- W2022793864 countsByYear W20227938642017 @default.
- W2022793864 countsByYear W20227938642020 @default.
- W2022793864 countsByYear W20227938642021 @default.
- W2022793864 crossrefType "journal-article" @default.
- W2022793864 hasAuthorship W2022793864A5002091038 @default.
- W2022793864 hasAuthorship W2022793864A5024369108 @default.
- W2022793864 hasAuthorship W2022793864A5054784713 @default.
- W2022793864 hasAuthorship W2022793864A5067621395 @default.
- W2022793864 hasAuthorship W2022793864A5083780796 @default.
- W2022793864 hasAuthorship W2022793864A5091408096 @default.
- W2022793864 hasConcept C136764020 @default.
- W2022793864 hasConcept C147483822 @default.
- W2022793864 hasConcept C153911025 @default.
- W2022793864 hasConcept C2777625466 @default.
- W2022793864 hasConcept C28406088 @default.
- W2022793864 hasConcept C41008148 @default.
- W2022793864 hasConcept C54355233 @default.
- W2022793864 hasConcept C55493867 @default.
- W2022793864 hasConcept C71928629 @default.
- W2022793864 hasConcept C86803240 @default.
- W2022793864 hasConceptScore W2022793864C136764020 @default.
- W2022793864 hasConceptScore W2022793864C147483822 @default.
- W2022793864 hasConceptScore W2022793864C153911025 @default.
- W2022793864 hasConceptScore W2022793864C2777625466 @default.
- W2022793864 hasConceptScore W2022793864C28406088 @default.
- W2022793864 hasConceptScore W2022793864C41008148 @default.
- W2022793864 hasConceptScore W2022793864C54355233 @default.
- W2022793864 hasConceptScore W2022793864C55493867 @default.
- W2022793864 hasConceptScore W2022793864C71928629 @default.
- W2022793864 hasConceptScore W2022793864C86803240 @default.
- W2022793864 hasIssue "3-4" @default.
- W2022793864 hasLocation W20227938641 @default.
- W2022793864 hasLocation W20227938642 @default.
- W2022793864 hasOpenAccess W2022793864 @default.
- W2022793864 hasPrimaryLocation W20227938641 @default.
- W2022793864 hasRelatedWork W2064833037 @default.
- W2022793864 hasRelatedWork W2086913556 @default.
- W2022793864 hasRelatedWork W2110746419 @default.
- W2022793864 hasRelatedWork W2150558096 @default.
- W2022793864 hasRelatedWork W2403828102 @default.
- W2022793864 hasRelatedWork W2769842444 @default.
- W2022793864 hasRelatedWork W2909752129 @default.
- W2022793864 hasRelatedWork W37460067 @default.
- W2022793864 hasRelatedWork W4241999781 @default.
- W2022793864 hasRelatedWork W2336925716 @default.
- W2022793864 hasVolume "103" @default.
- W2022793864 isParatext "false" @default.
- W2022793864 isRetracted "false" @default.
- W2022793864 magId "2022793864" @default.
- W2022793864 workType "article" @default.