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• W2022795575 abstract "We screened a set of Saccharomyces cerevisiae deletion mutants for resistance to killer toxin HM-1, which kills susceptible yeasts through inhibiting 1,3-beta-glucan synthase. By using HM-1 plate assay, we found that eight gene-deletion mutants had higher HM-1-resistance compared with the wild-type. Among these eight genes, five--ALG3, CAX4, MNS1, OST6 and YBL083C--were associated with N-glycan formation and maturation. The ALG3 gene has been shown before to be highly resistant to HM-1. The YBL083C gene may be a dubious open reading frame that overlaps partially the ALG3 gene. The deletion mutant of the MNS1 gene that encodes 1,2-alpha-mannosidase showed with a 13-fold higher HM-1 resistance compared with the wild-type. By HM-1 binding assay, the yeast plasma membrane fraction of alg3 and mns1 cells had less binding ability compared with wild-type cells. These results indicate that the presence of the terminal 1,3-alpha-linked mannose residue of the B-chain of the N-glycan structure is essential for interaction with HM-1. A deletion mutant of aquaglyceroporin Fps1p also showed increased HM-1 resistance. A deletion mutant of osmoregulatory mitogen-activated protein kinase Hog1p was more sensitive to HM-1, suggesting that high-osmolarity glycerol pathways plays an important role in the compensatory response to HM-1 action." @default.
• W2022795575 created "2016-06-24" @default.
• W2022795575 creator A5000544104 @default.
• W2022795575 creator A5036273084 @default.
• W2022795575 creator A5058239639 @default.
• W2022795575 date "2010-08-27" @default.
• W2022795575 modified "2023-09-25" @default.
• W2022795575 title "Genome-wide screen of Saccharomyces cerevisiae for killer toxin HM-1 resistance" @default.
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• W2022795575 doi "https://doi.org/10.1002/yea.1818" @default.
• W2022795575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20803478" @default.
• W2022795575 hasPublicationYear "2010" @default.
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