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- W2022795644 startingPage "36" @default.
- W2022795644 abstract "The iatrogenic risks associated with excessive Mn administration in parenteral nutrition (PN) patients are well documented. Hypermanganesemia and neurotoxicity are associated with the duration of Mn supplementation, Mn dosage, as well as pathological conditions, such as anemia or cholestasis. Recent PN guidelines recommend the biomonitoring of patients if they receive Mn in their PN longer than 30 days. The data in the literature are conflicting about the method for assessing Mn stores in humans as a definitive biomarker of Mn exposure or induced-neurotoxicity has yet to be identified. The biomonitoring of Mn relies on the analysis of whole blood Mn (WB Mn) levels, which are highly variable among human population and are not strictly correlated with Mn-induced neurotoxicity. Alterations in dopaminergic (DAergic) and catecholaminergic metabolism have been studied as predictive biomarkers of Mn-induced neurotoxicity. Given these limitations, this review addresses various approaches for biomonitoring Mn exposure and neurotoxic risk." @default.
- W2022795644 created "2016-06-24" @default.
- W2022795644 creator A5029074918 @default.
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- W2022795644 creator A5043363715 @default.
- W2022795644 creator A5070219261 @default.
- W2022795644 creator A5071579573 @default.
- W2022795644 date "2014-07-01" @default.
- W2022795644 modified "2023-09-30" @default.
- W2022795644 title "Manganese in human parenteral nutrition: Considerations for toxicity and biomonitoring" @default.
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