FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022797056> ?p ?o ?g. }

• W2022797056 endingPage "10695" @default.
• W2022797056 startingPage "10691" @default.
• W2022797056 abstract "Perception and response to nutritional iron availability by bacteria are essential to control cellular iron homeostasis. The Irr protein from Bradyrhizobium japonicum senses iron through the status of heme biosynthesis to globally regulate iron-dependent gene expression. Heme binds directly to Irr to trigger its degradation. Here, we show that severe manganese limitation created by growth of a Mn 2+ transport mutant in manganese-limited media resulted in a cellular iron deficiency. In wild-type cells, Irr levels were attenuated under manganese limitation, resulting in reduced promoter occupancy of target genes and altered iron-dependent gene expression. Irr levels were high regardless of manganese availability in a heme-deficient mutant, indicating that manganese normally affects heme-dependent degradation of Irr. Manganese altered the secondary structure of Irr in vitro and inhibited binding of heme to the protein. We propose that manganese limitation destabilizes Irr under low-iron conditions by lowering the threshold of heme that can trigger Irr degradation. The findings implicate a mechanism for the control of iron homeostasis by manganese in a bacterium." @default.
• W2022797056 created "2016-06-24" @default.
• W2022797056 creator A5042515687 @default.
• W2022797056 creator A5060499423 @default.
• W2022797056 creator A5078135767 @default.
• W2022797056 date "2010-05-24" @default.
• W2022797056 modified "2023-10-03" @default.
• W2022797056 title "Control of bacterial iron homeostasis by manganese" @default.
• W2022797056 cites W1520065949 @default.
• W2022797056 cites W1543687525 @default.
• W2022797056 cites W1832431421 @default.
• W2022797056 cites W1981318141 @default.
• W2022797056 cites W1990411368 @default.
• W2022797056 cites W1999259053 @default.
• W2022797056 cites W2011954917 @default.
• W2022797056 cites W2014723793 @default.
• W2022797056 cites W2020866878 @default.
• W2022797056 cites W2026772411 @default.
• W2022797056 cites W2026849306 @default.
• W2022797056 cites W2029777043 @default.
• W2022797056 cites W2035034473 @default.
• W2022797056 cites W2035594105 @default.
• W2022797056 cites W2060866305 @default.
• W2022797056 cites W2072058887 @default.
• W2022797056 cites W2073215410 @default.
• W2022797056 cites W2075206000 @default.
• W2022797056 cites W2091989374 @default.
• W2022797056 cites W2093427530 @default.
• W2022797056 cites W2099888935 @default.
• W2022797056 cites W2099910134 @default.
• W2022797056 cites W2102624197 @default.
• W2022797056 cites W2124765964 @default.
• W2022797056 cites W2130107423 @default.
• W2022797056 cites W2150019542 @default.
• W2022797056 cites W2150283079 @default.
• W2022797056 cites W2159714389 @default.
• W2022797056 cites W2165246198 @default.
• W2022797056 cites W2339865272 @default.
• W2022797056 doi "https://doi.org/10.1073/pnas.1002342107" @default.
• W2022797056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2890801" @default.
• W2022797056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20498065" @default.
• W2022797056 hasPublicationYear "2010" @default.
• W2022797056 type Work @default.
• W2022797056 sameAs 2022797056 @default.
• W2022797056 citedByCount "56" @default.
• W2022797056 countsByYear W20227970562012 @default.
• W2022797056 countsByYear W20227970562013 @default.
• W2022797056 countsByYear W20227970562014 @default.
• W2022797056 countsByYear W20227970562015 @default.
• W2022797056 countsByYear W20227970562016 @default.
• W2022797056 countsByYear W20227970562017 @default.
• W2022797056 countsByYear W20227970562019 @default.
• W2022797056 countsByYear W20227970562020 @default.
• W2022797056 countsByYear W20227970562021 @default.
• W2022797056 countsByYear W20227970562022 @default.
• W2022797056 countsByYear W20227970562023 @default.
• W2022797056 crossrefType "journal-article" @default.
• W2022797056 hasAuthorship W2022797056A5042515687 @default.
• W2022797056 hasAuthorship W2022797056A5060499423 @default.
• W2022797056 hasAuthorship W2022797056A5078135767 @default.
• W2022797056 hasBestOaLocation W20227970561 @default.
• W2022797056 hasConcept C104317684 @default.
• W2022797056 hasConcept C143065580 @default.
• W2022797056 hasConcept C178790620 @default.
• W2022797056 hasConcept C181199279 @default.
• W2022797056 hasConcept C185592680 @default.
• W2022797056 hasConcept C2776217839 @default.
• W2022797056 hasConcept C523546767 @default.
• W2022797056 hasConcept C528890316 @default.
• W2022797056 hasConcept C54355233 @default.
• W2022797056 hasConcept C55493867 @default.
• W2022797056 hasConcept C86803240 @default.
• W2022797056 hasConcept C95444343 @default.
• W2022797056 hasConceptScore W2022797056C104317684 @default.
• W2022797056 hasConceptScore W2022797056C143065580 @default.
• W2022797056 hasConceptScore W2022797056C178790620 @default.
• W2022797056 hasConceptScore W2022797056C181199279 @default.
• W2022797056 hasConceptScore W2022797056C185592680 @default.
• W2022797056 hasConceptScore W2022797056C2776217839 @default.
• W2022797056 hasConceptScore W2022797056C523546767 @default.
• W2022797056 hasConceptScore W2022797056C528890316 @default.
• W2022797056 hasConceptScore W2022797056C54355233 @default.
• W2022797056 hasConceptScore W2022797056C55493867 @default.
• W2022797056 hasConceptScore W2022797056C86803240 @default.
• W2022797056 hasConceptScore W2022797056C95444343 @default.
• W2022797056 hasIssue "23" @default.
• W2022797056 hasLocation W20227970561 @default.
• W2022797056 hasLocation W20227970562 @default.
• W2022797056 hasLocation W20227970563 @default.
• W2022797056 hasLocation W20227970564 @default.
• W2022797056 hasOpenAccess W2022797056 @default.
• W2022797056 hasPrimaryLocation W20227970561 @default.
• W2022797056 hasRelatedWork W2038016246 @default.
• W2022797056 hasRelatedWork W2040376904 @default.
• W2022797056 hasRelatedWork W2042148673 @default.
• W2022797056 hasRelatedWork W2080663249 @default.
• W2022797056 hasRelatedWork W2156674132 @default.
• W2022797056 hasRelatedWork W2329199018 @default.

• next