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• W2022797206 abstract "Goal Recent studies suggest an increasing prevalence of atypical initial symptoms in patients with celiac disease (CD). The aim of this study was to compare the presenting symptoms of CD at 2 comparable referral institutions in South Florida, and in Ankara, Turkey. We retrospectively reviewed the records of patients with an initial diagnosis of CD by small bowel biopsy during the same (1991 to 2001) 10-year period at Cleveland Clinic Florida and University of Ankara, Turkey. A numerical score was assigned to presenting symptom and signs. Results There were 28 patients in the South Florida group (51% men) and 40 patients in the Turkish group (35% men) (P=NS). The Turkish patients were significantly younger at diagnosis (36±2 y vs. US patients 66±3 y) (P<0.0001). Typical celiac symptom scores were similar (Turkey 1.1±0.2 vs. South Florida 1.3±0.3) (P=NS). Atypical symptom scores were significantly higher in the US patients (1.9±0.2) versus those from Turkey (1.2±0.1) (P<0.01). The Turkish patients were significantly more likely (P<0.01) to present with chronic diarrhea, hypoalbuminemia, and mactocytosis at the time of diagnosis. Conclusions Although retrospective, this study points to striking differences in the clinical presentation of CD in individuals in South Florida, United States, and Ankara, Turkey, diagnosed during the same time period at both institutions. Turkish patients were younger, and more likely to present with chronic diarrhea, hypoalbuminemia, and microcytosis—as was more commonly seen in the United States in the 1960s and 70s. These findings raise the question of an interplay of demographics with diet and genetics in the presenting symptoms of CD in these 2 distant geographic areas." @default.
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• W2022797206 date "2008-01-01" @default.
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• W2022797206 title "A Tale of Two Cities" @default.
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• W2022797206 doi "https://doi.org/10.1097/01.mcg.0000247998.57828.f7" @default.
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