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• W2022798691 abstract "Knee meniscus fibrocartilage is frequently injured, resulting in approximately 1 million procedures annually in the US and Europe. Its near-avascularity contributes heavily to its inability to heal, and places it as a prime candidate for replacement through regenerative medicine. Here, we describe a novel approach to increase extracellular matrix organization, rather than content, in order to augment the mechanical properties of engineered tissue. To synthesize fibrocartilage, we employ a self-assembling process, which is free of exogenous scaffolds and relies on cell-to-cell interactions to form all-biologic constructs. When treated with the signaling phospholipid lysophosphatidic acid (LPA), tissue constructs displayed increased tensile properties and collagen organization, while total collagen content remained unchanged. LPA-treated constructs exhibited greater DNA content, indicative that the molecule exerted a signaling effect. Furthermore, LPA-treated cells displayed significant cytoskeletal reorganization. We conclude that LPA induced cytoskeletal reorganization and cell-matrix traction, which resulted in matrix reorganization and increased tensile properties. This study emphasizes the potential of non-traditional stimuli, such as signaling phospholipids, for use in tissue development studies. The extension of these results to other collagen-rich tissues represents a promising avenue for future exploration." @default.
• W2022798691 created "2016-06-24" @default.
• W2022798691 creator A5001646095 @default.
• W2022798691 creator A5055236369 @default.
• W2022798691 date "2013-03-01" @default.
• W2022798691 modified "2023-09-27" @default.
• W2022798691 title "Enhancing the mechanical properties of engineered tissue through matrix remodeling via the signaling phospholipid lysophosphatidic acid" @default.
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• W2022798691 doi "https://doi.org/10.1016/j.bbrc.2013.02.048" @default.
• W2022798691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3626273" @default.
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