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• W2022798715 abstract "SUMMARY The cellular immune response probably plays a pivotal role in determining the clinical outcome after exposure to Mycobacterium tuberculosis. We used multi-parameter flow-cytometry to evaluate the distribution of T-lymphocyte subsets during infection and disease caused by M. tuberculosis. Samples were obtained from 71 volunteers to identify the T CD4+ and CD8+ lymphocyte numbers, and the activation plus memory/naïve phenotypes, as defined by CD38, HLA-DR, CD45RA and CD27 markers. Subjects were divided into 18 healthy volunteers without detectable reaction to purified protein derivative (PPD−), 18 health care workers with a recent conversion to PPD, 20 patients with active pulmonary tuberculosis (TBC) and 15 patients with treated TBC at 6 months of therapy. By multiple-comparison analyses, the T CD4+ lymphocyte number of the TBC group was lower than the PPD– group (P &lt; 0·05). This difference was apparently lost after treatment. The higher and the lower number of naïve T CD4+ cells was observed in the PPD– and TBC group, respectively. CD8+ T lymphocytes were also statistically different among the four groups (P = 0·0002), lower in the TBC group (P &lt; 0·05). CD8+ T lymphocyte activation was evaluated by the CD38 and HLA-DR surface expression. The percentage distribution of these markers was statistically different between the four groups (P = 0·0055). TBC patients had a higher percentage of CD38+ cells and mean fluorescence index, suggesting an overall increase of cell activation. These results suggest that peripheral T lymphocytes reflect cellular activation during TBC, along with possible redistribution of naïve, memory/effector and late differentiated memory/effector phenotypes in the peripheral blood after infection and disease caused by M. tuberculosis." @default.
• W2022798715 created "2016-06-24" @default.
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• W2022798715 date "2002-04-01" @default.
• W2022798715 modified "2023-10-16" @default.
• W2022798715 title "Immunophenotypic characterization of peripheral T lymphocytes in<i>Mycobacterium tuberculosis</i>infection and disease" @default.
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• W2022798715 doi "https://doi.org/10.1046/j.1365-2249.2002.01809.x" @default.
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