FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022800519> ?p ?o ?g. }

• W2022800519 abstract "The apolipoprotein E family contains three major isoforms (ApoE4, E3, and E2) that are directly involved with lipoprotein metabolism and cholesterol transport. ApoE3 and apoE4 differ in only a single amino acid with an arginine in apoE4 changed to a cysteine at position 112 in apoE3. Yet only apoE4 is recognized as a risk factor for Alzheimer's disease. Here we used 19F NMR to examine structural differences between apoE4 and apoE3 and the effect of the C-terminal domain on the N-terminal domain. After incorporation of 5-19F-tryptophan the 1D 19F NMR spectra were compared for the N-terminal domain and for the full length proteins. The NMR spectra of the N-terminal region (residues 1–191) are reasonably well resolved while those of the full length wild-type proteins are broad and ill-defined suggesting considerable conformational heterogeneity. At least four of the seven tryptophan residues in the wild type protein appear to be solvent exposed. NMR spectra of the wild-type proteins were compared to apoE containing four mutations in the C-terminal region that gives rise to a monomeric form either of apoE3 under native conditions (Zhang et al., Biochemistry 2007; 46: 10722–10732) or apoE4 in the presence of 1 M urea. For either wild-type or mutant proteins the differences in tryptophan resonances in the N-terminal region of the protein suggest structural differences between apoE3 and apoE4. We conclude that these differences occur both as a consequence of the Arg158Cys mutation and as a consequence of the interaction with the C-terminal domain." @default.
• W2022800519 created "2016-06-24" @default.
• W2022800519 creator A5005869812 @default.
• W2022800519 creator A5033062872 @default.
• W2022800519 creator A5043445006 @default.
• W2022800519 creator A5058092701 @default.
• W2022800519 date "2010-01-01" @default.
• W2022800519 modified "2023-09-29" @default.
• W2022800519 title "Structural Differences Between Apolipoprotein E3 and E4 as Measured by 19F- NMR" @default.
• W2022800519 cites W1490077018 @default.
• W2022800519 cites W1522309562 @default.
• W2022800519 cites W1900420888 @default.
• W2022800519 cites W1964882696 @default.
• W2022800519 cites W1976725721 @default.
• W2022800519 cites W1984737558 @default.
• W2022800519 cites W1986838916 @default.
• W2022800519 cites W1990083881 @default.
• W2022800519 cites W1994543234 @default.
• W2022800519 cites W1999478880 @default.
• W2022800519 cites W1999631936 @default.
• W2022800519 cites W2007929153 @default.
• W2022800519 cites W2026514423 @default.
• W2022800519 cites W2029332947 @default.
• W2022800519 cites W2036362108 @default.
• W2022800519 cites W2038263678 @default.
• W2022800519 cites W2050255138 @default.
• W2022800519 cites W2051394059 @default.
• W2022800519 cites W2053867269 @default.
• W2022800519 cites W2056451248 @default.
• W2022800519 cites W2059158694 @default.
• W2022800519 cites W2067976699 @default.
• W2022800519 cites W2073480313 @default.
• W2022800519 cites W2076775566 @default.
• W2022800519 cites W2159786214 @default.
• W2022800519 cites W2401829918 @default.
• W2022800519 cites W89251363 @default.
• W2022800519 cites W98152484 @default.
• W2022800519 doi "https://doi.org/10.1016/j.bpj.2009.12.3577" @default.
• W2022800519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2817840" @default.
• W2022800519 hasPublicationYear "2010" @default.
• W2022800519 type Work @default.
• W2022800519 sameAs 2022800519 @default.
• W2022800519 citedByCount "1" @default.
• W2022800519 crossrefType "journal-article" @default.
• W2022800519 hasAuthorship W2022800519A5005869812 @default.
• W2022800519 hasAuthorship W2022800519A5033062872 @default.
• W2022800519 hasAuthorship W2022800519A5043445006 @default.
• W2022800519 hasAuthorship W2022800519A5058092701 @default.
• W2022800519 hasBestOaLocation W20228005191 @default.
• W2022800519 hasConcept C104317684 @default.
• W2022800519 hasConcept C121332964 @default.
• W2022800519 hasConcept C126322002 @default.
• W2022800519 hasConcept C1276947 @default.
• W2022800519 hasConcept C143065580 @default.
• W2022800519 hasConcept C181199279 @default.
• W2022800519 hasConcept C185592680 @default.
• W2022800519 hasConcept C207583985 @default.
• W2022800519 hasConcept C2776706248 @default.
• W2022800519 hasConcept C2777468819 @default.
• W2022800519 hasConcept C2778163477 @default.
• W2022800519 hasConcept C2779134260 @default.
• W2022800519 hasConcept C2779201268 @default.
• W2022800519 hasConcept C4839761 @default.
• W2022800519 hasConcept C515207424 @default.
• W2022800519 hasConcept C55493867 @default.
• W2022800519 hasConcept C57089818 @default.
• W2022800519 hasConcept C62746215 @default.
• W2022800519 hasConcept C67787023 @default.
• W2022800519 hasConcept C71240020 @default.
• W2022800519 hasConcept C71924100 @default.
• W2022800519 hasConceptScore W2022800519C104317684 @default.
• W2022800519 hasConceptScore W2022800519C121332964 @default.
• W2022800519 hasConceptScore W2022800519C126322002 @default.
• W2022800519 hasConceptScore W2022800519C1276947 @default.
• W2022800519 hasConceptScore W2022800519C143065580 @default.
• W2022800519 hasConceptScore W2022800519C181199279 @default.
• W2022800519 hasConceptScore W2022800519C185592680 @default.
• W2022800519 hasConceptScore W2022800519C207583985 @default.
• W2022800519 hasConceptScore W2022800519C2776706248 @default.
• W2022800519 hasConceptScore W2022800519C2777468819 @default.
• W2022800519 hasConceptScore W2022800519C2778163477 @default.
• W2022800519 hasConceptScore W2022800519C2779134260 @default.
• W2022800519 hasConceptScore W2022800519C2779201268 @default.
• W2022800519 hasConceptScore W2022800519C4839761 @default.
• W2022800519 hasConceptScore W2022800519C515207424 @default.
• W2022800519 hasConceptScore W2022800519C55493867 @default.
• W2022800519 hasConceptScore W2022800519C57089818 @default.
• W2022800519 hasConceptScore W2022800519C62746215 @default.
• W2022800519 hasConceptScore W2022800519C67787023 @default.
• W2022800519 hasConceptScore W2022800519C71240020 @default.
• W2022800519 hasConceptScore W2022800519C71924100 @default.
• W2022800519 hasLocation W20228005191 @default.
• W2022800519 hasOpenAccess W2022800519 @default.
• W2022800519 hasPrimaryLocation W20228005191 @default.
• W2022800519 hasRelatedWork W1973341288 @default.
• W2022800519 hasRelatedWork W1973569072 @default.
• W2022800519 hasRelatedWork W1977311675 @default.
• W2022800519 hasRelatedWork W1991198565 @default.
• W2022800519 hasRelatedWork W1995465099 @default.
• W2022800519 hasRelatedWork W1998061807 @default.

• next