FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022800946> ?p ?o ?g. }

• W2022800946 endingPage "491" @default.
• W2022800946 startingPage "486" @default.
• W2022800946 abstract "Simvastatin is primarily metabolized by CYP3A4. A combined CYP3A4/5 genotype classification, combining the decrease-of-function CYP3A4*22 and the loss-of-function CYP3A5*3, has recently been reported. We aim to determine whether CYP3A4*22 and CYP3A5*3 alleles are associated with increased plasma concentrations of simvastatin lactone (SV) and simvastatin acid (SVA). This is the first report evaluating associations between in-vivo simvastatin concentrations and CYP3A4*22, alone or in a combined CYP3A4/5 genotype-defined classification.Genotypes and simvastatin concentrations were determined for 830 participants (555 Whites and 275 African-Americans) in the Cholesterol and Pharmacogenomics clinical trial with 40 mg/day simvastatin for 6 weeks. Concentrations were determined in 12-h postdose samples. Associations between simvastatin concentrations and CYP3A4*22 and CYP3A5*3 alleles were tested separately and in a combined CYP3A4/5 genotype-defined classification system.In Whites, CYP3A4*22 carriers (n=42) had 14% higher SVA (P=0.04) and 20% higher SV (P=0.06) compared with noncarriers (n=513). CYP3A5*3 allele status was not significantly associated with SV or SVA in Whites. In African-Americans, CYP3A4*22 carriers (n=8) had 170% higher SV (P<0.01) than noncarriers (n=267), but no significant difference was detected for SVA. African-American CYP3A5 nonexpressors (n=28) had 33% higher SV (P=0.02) than CYP3A5 expressors (n=247), but no significant difference was detected for SVA. For both races, SV appeared to decrease across the rank-ordered combined CYP3A4/5 genotype-defined groups (poor, intermediate, and extensive metabolizers); however, similar trends were not observed for SVA.Genetic variation in CYP3A4 was associated with plasma simvastatin concentrations in self-reported Whites. Genetic variations in CYP3A4 and CYP3A5 were associated with plasma simvastatin concentrations in self-reported African-Americans." @default.
• W2022800946 created "2016-06-24" @default.
• W2022800946 creator A5031699767 @default.
• W2022800946 creator A5049741747 @default.
• W2022800946 creator A5059664993 @default.
• W2022800946 creator A5074148505 @default.
• W2022800946 creator A5076610908 @default.
• W2022800946 date "2014-10-01" @default.
• W2022800946 modified "2023-10-05" @default.
• W2022800946 title "CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort" @default.
• W2022800946 cites W1548555206 @default.
• W2022800946 cites W2017098712 @default.
• W2022800946 cites W2018643176 @default.
• W2022800946 cites W2029573792 @default.
• W2022800946 cites W2031155689 @default.
• W2022800946 cites W2032584539 @default.
• W2022800946 cites W2054539038 @default.
• W2022800946 cites W2080228333 @default.
• W2022800946 cites W2110078378 @default.
• W2022800946 cites W2117529616 @default.
• W2022800946 cites W2151093881 @default.
• W2022800946 cites W2151586219 @default.
• W2022800946 cites W2160393958 @default.
• W2022800946 cites W2169831150 @default.
• W2022800946 doi "https://doi.org/10.1097/fpc.0000000000000079" @default.
• W2022800946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4160394" @default.
• W2022800946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25051018" @default.
• W2022800946 hasPublicationYear "2014" @default.
• W2022800946 type Work @default.
• W2022800946 sameAs 2022800946 @default.
• W2022800946 citedByCount "37" @default.
• W2022800946 countsByYear W20228009462015 @default.
• W2022800946 countsByYear W20228009462016 @default.
• W2022800946 countsByYear W20228009462017 @default.
• W2022800946 countsByYear W20228009462018 @default.
• W2022800946 countsByYear W20228009462019 @default.
• W2022800946 countsByYear W20228009462020 @default.
• W2022800946 countsByYear W20228009462021 @default.
• W2022800946 countsByYear W20228009462022 @default.
• W2022800946 countsByYear W20228009462023 @default.
• W2022800946 crossrefType "journal-article" @default.
• W2022800946 hasAuthorship W2022800946A5031699767 @default.
• W2022800946 hasAuthorship W2022800946A5049741747 @default.
• W2022800946 hasAuthorship W2022800946A5059664993 @default.
• W2022800946 hasAuthorship W2022800946A5074148505 @default.
• W2022800946 hasAuthorship W2022800946A5076610908 @default.
• W2022800946 hasBestOaLocation W20228009461 @default.
• W2022800946 hasConcept C104317684 @default.
• W2022800946 hasConcept C109650736 @default.
• W2022800946 hasConcept C126322002 @default.
• W2022800946 hasConcept C134018914 @default.
• W2022800946 hasConcept C135763542 @default.
• W2022800946 hasConcept C180754005 @default.
• W2022800946 hasConcept C185592680 @default.
• W2022800946 hasConcept C2776329913 @default.
• W2022800946 hasConcept C526171541 @default.
• W2022800946 hasConcept C54355233 @default.
• W2022800946 hasConcept C55775858 @default.
• W2022800946 hasConcept C62231903 @default.
• W2022800946 hasConcept C71924100 @default.
• W2022800946 hasConcept C72563966 @default.
• W2022800946 hasConcept C86803240 @default.
• W2022800946 hasConcept C92137452 @default.
• W2022800946 hasConcept C98274493 @default.
• W2022800946 hasConceptScore W2022800946C104317684 @default.
• W2022800946 hasConceptScore W2022800946C109650736 @default.
• W2022800946 hasConceptScore W2022800946C126322002 @default.
• W2022800946 hasConceptScore W2022800946C134018914 @default.
• W2022800946 hasConceptScore W2022800946C135763542 @default.
• W2022800946 hasConceptScore W2022800946C180754005 @default.
• W2022800946 hasConceptScore W2022800946C185592680 @default.
• W2022800946 hasConceptScore W2022800946C2776329913 @default.
• W2022800946 hasConceptScore W2022800946C526171541 @default.
• W2022800946 hasConceptScore W2022800946C54355233 @default.
• W2022800946 hasConceptScore W2022800946C55775858 @default.
• W2022800946 hasConceptScore W2022800946C62231903 @default.
• W2022800946 hasConceptScore W2022800946C71924100 @default.
• W2022800946 hasConceptScore W2022800946C72563966 @default.
• W2022800946 hasConceptScore W2022800946C86803240 @default.
• W2022800946 hasConceptScore W2022800946C92137452 @default.
• W2022800946 hasConceptScore W2022800946C98274493 @default.
• W2022800946 hasIssue "10" @default.
• W2022800946 hasLocation W20228009461 @default.
• W2022800946 hasLocation W20228009462 @default.
• W2022800946 hasLocation W20228009463 @default.
• W2022800946 hasLocation W20228009464 @default.
• W2022800946 hasLocation W20228009465 @default.
• W2022800946 hasLocation W20228009466 @default.
• W2022800946 hasOpenAccess W2022800946 @default.
• W2022800946 hasPrimaryLocation W20228009461 @default.
• W2022800946 hasRelatedWork W1974808961 @default.
• W2022800946 hasRelatedWork W2022800946 @default.
• W2022800946 hasRelatedWork W2039613248 @default.
• W2022800946 hasRelatedWork W2050245455 @default.
• W2022800946 hasRelatedWork W2167831565 @default.
• W2022800946 hasRelatedWork W2335837408 @default.
• W2022800946 hasRelatedWork W2547425061 @default.
• W2022800946 hasRelatedWork W2748952813 @default.

• next