Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022803237> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2022803237 endingPage "136" @default.
- W2022803237 startingPage "123" @default.
- W2022803237 abstract "We report here evidence for intramolecular-induced suppression of the in vivo antibody response in fish, using a panel of T-dependent hapten-carrier antigens. Atlantic salmon were immunized intraperitoneally with protein antigens (Limulus polyphemus hemocyanin, chicken gamma globulin, and Aeromonas salmonicida A-layer protein) given in their native form or haptenated with either 4-hydroxy-3-iodo-5-nitrophenyl-acetic acid (NIP), 2,4,6-trinitrophenyl-acetic acid (TNP), or fluorescein-5-iso-thiocyanate (FITC). The salmon immune system responds to these haptencarrier antigens by eliciting high anti-hapten titers whereas the antibody titers against protein determinants were suppressed 87–99%, determined by ELISA. NIP also induced suppression of the anti-FITC response when NIP and FITC were intramolecularly conjugated to Limulus polyphemus hemocyanin (LPH). The suppression was found to be independent of haptenation ratios and time after immunization. The possibility that haptenation interferes with or blocks the protein determinants is not likely because antisera raised against native LPH recognize LPH-specific epitopes even on heavily NIP-substituted LPH. Although the mechanism behind intramolecular-induced suppression is poorly understood, even in mammals, this study demonstrates that intramolecular-induced suppression may be one means by which antibody responses in fish are regulated. The possible impact of antigen-induced suppression on immune responses against vaccine antigens in fish is discussed." @default.
- W2022803237 created "2016-06-24" @default.
- W2022803237 creator A5018013781 @default.
- W2022803237 creator A5067485764 @default.
- W2022803237 date "1994-03-01" @default.
- W2022803237 modified "2023-09-29" @default.
- W2022803237 title "Immunoregulation in fish I: Intramolecular-induced suppression of antibody responses to haptenated protein antigens studied in Atlantic salmon (Salmo salar L)" @default.
- W2022803237 cites W1154758160 @default.
- W2022803237 cites W1521203131 @default.
- W2022803237 cites W1579182841 @default.
- W2022803237 cites W1588766933 @default.
- W2022803237 cites W1972568898 @default.
- W2022803237 cites W1973265912 @default.
- W2022803237 cites W1976110676 @default.
- W2022803237 cites W1978556174 @default.
- W2022803237 cites W1979918118 @default.
- W2022803237 cites W1986181736 @default.
- W2022803237 cites W1999959730 @default.
- W2022803237 cites W2002361099 @default.
- W2022803237 cites W2005944558 @default.
- W2022803237 cites W2017176041 @default.
- W2022803237 cites W2017364282 @default.
- W2022803237 cites W2018945366 @default.
- W2022803237 cites W2023246725 @default.
- W2022803237 cites W2024904315 @default.
- W2022803237 cites W2030450068 @default.
- W2022803237 cites W2030568515 @default.
- W2022803237 cites W2033103432 @default.
- W2022803237 cites W2035712637 @default.
- W2022803237 cites W2038820650 @default.
- W2022803237 cites W2051376821 @default.
- W2022803237 cites W2060640530 @default.
- W2022803237 cites W2068111943 @default.
- W2022803237 cites W2071659312 @default.
- W2022803237 cites W2074646054 @default.
- W2022803237 cites W2075620652 @default.
- W2022803237 cites W2118066866 @default.
- W2022803237 cites W2152371641 @default.
- W2022803237 cites W2317493325 @default.
- W2022803237 cites W4211138062 @default.
- W2022803237 doi "https://doi.org/10.1016/0145-305x(94)90240-2" @default.
- W2022803237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7521853" @default.
- W2022803237 hasPublicationYear "1994" @default.
- W2022803237 type Work @default.
- W2022803237 sameAs 2022803237 @default.
- W2022803237 citedByCount "17" @default.
- W2022803237 countsByYear W20228032372012 @default.
- W2022803237 countsByYear W20228032372020 @default.
- W2022803237 crossrefType "journal-article" @default.
- W2022803237 hasAuthorship W2022803237A5018013781 @default.
- W2022803237 hasAuthorship W2022803237A5067485764 @default.
- W2022803237 hasConcept C147483822 @default.
- W2022803237 hasConcept C151730666 @default.
- W2022803237 hasConcept C153911025 @default.
- W2022803237 hasConcept C159654299 @default.
- W2022803237 hasConcept C203014093 @default.
- W2022803237 hasConcept C2776487282 @default.
- W2022803237 hasConcept C2779915011 @default.
- W2022803237 hasConcept C2780868878 @default.
- W2022803237 hasConcept C29144244 @default.
- W2022803237 hasConcept C86803240 @default.
- W2022803237 hasConceptScore W2022803237C147483822 @default.
- W2022803237 hasConceptScore W2022803237C151730666 @default.
- W2022803237 hasConceptScore W2022803237C153911025 @default.
- W2022803237 hasConceptScore W2022803237C159654299 @default.
- W2022803237 hasConceptScore W2022803237C203014093 @default.
- W2022803237 hasConceptScore W2022803237C2776487282 @default.
- W2022803237 hasConceptScore W2022803237C2779915011 @default.
- W2022803237 hasConceptScore W2022803237C2780868878 @default.
- W2022803237 hasConceptScore W2022803237C29144244 @default.
- W2022803237 hasConceptScore W2022803237C86803240 @default.
- W2022803237 hasIssue "2" @default.
- W2022803237 hasLocation W20228032371 @default.
- W2022803237 hasLocation W20228032372 @default.
- W2022803237 hasOpenAccess W2022803237 @default.
- W2022803237 hasPrimaryLocation W20228032371 @default.
- W2022803237 hasRelatedWork W1502102164 @default.
- W2022803237 hasRelatedWork W1660314667 @default.
- W2022803237 hasRelatedWork W1989413225 @default.
- W2022803237 hasRelatedWork W2013089263 @default.
- W2022803237 hasRelatedWork W2023289803 @default.
- W2022803237 hasRelatedWork W2064480866 @default.
- W2022803237 hasRelatedWork W2065806719 @default.
- W2022803237 hasRelatedWork W2151540162 @default.
- W2022803237 hasRelatedWork W2411451838 @default.
- W2022803237 hasRelatedWork W2414662090 @default.
- W2022803237 hasVolume "18" @default.
- W2022803237 isParatext "false" @default.
- W2022803237 isRetracted "false" @default.
- W2022803237 magId "2022803237" @default.
- W2022803237 workType "article" @default.