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- W2022803309 abstract "1–2 Annulated adamantane piperidines 4, 6, 16, 17, 19, 23 and 25 were synthesized and evaluated for anti-influenza A virus activity. The stereoelectronic requirements for optimal antiviral potency were investigated. Piperidine 23 proved to be the most active of the compounds tested against influenza A virus, being 3.5-fold more active than amantadine, equipotent to rimantadine and 15-fold more potent than ribavirin. It is noteworthy that piperidine 23 displayed one of the highest selectivity indexes (SI > 732) among aminoadamantanes or other cage structure amines tested till now." @default.
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- W2022803309 date "2009-02-01" @default.
- W2022803309 modified "2023-10-09" @default.
- W2022803309 title "Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity" @default.
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- W2022803309 doi "https://doi.org/10.1016/j.bmc.2009.01.009" @default.
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