FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022803933> ?p ?o ?g. }

• W2022803933 endingPage "30" @default.
• W2022803933 startingPage "21" @default.
• W2022803933 abstract "Summary We have previously characterized the keratin 14 interleukin-4-transgenic (IL-4-Tg) mouse model of atopic dermatitis as a chronic pruritic inflammatory skin disease typified by skin infiltration of inflammatory cells and early up-regulation of Th2 cytokines and late surge of Th1 cytokines. In the present study, we examined the involvement of B cells. Systematic examinations of the following immunological parameters on B cells were carried out in non-Tg control mice and in IL-4-Tg mice at before disease onset and early and late disease stages so that we could determine the immunological sequence of events leading to the disease development: surface expressions of IA/IE, activation and costimulatory molecules, proliferation under LPS or IgM stimulation, quantification of cell surface and serum IgE, IgG1, and IgG2a. Our results showed that as the disease progresses from before onset to early disease and to late disease, there is a parallel increase in surface markers of B cell activation (IA/IE, CD44, CD69, CD80 and CD86), in B cell proliferation, and in cell surface and serum IgE. Significant increases of Th2-driven serum IgG1 and IgE in early disease was followed by significant increase of Th1-driven IgG2a in late disease. Importantly the significant increases of activation molecule (IA/IE), proliferation (to LPS), and surface IgE on B cells of the IL-4-Tg mice precedes the up-regulation of serum IgE and disease onset. These data suggest that activated B cells may play a role in atopic dermatitis disease development by up-regulating serum IgE concentration, which serves as a marker of disease onset." @default.
• W2022803933 created "2016-06-24" @default.
• W2022803933 creator A5030763743 @default.
• W2022803933 creator A5044316005 @default.
• W2022803933 creator A5053469409 @default.
• W2022803933 creator A5082934826 @default.
• W2022803933 creator A5088144526 @default.
• W2022803933 date "2005-07-28" @default.
• W2022803933 modified "2023-10-14" @default.
• W2022803933 title "The disease progression in the keratin 14 IL-4-transgenic mouse model of atopic dermatitis parallels the up-regulation of B cell activation molecules, proliferation and surface and serum IgE" @default.
• W2022803933 cites W1533670525 @default.
• W2022803933 cites W1577146075 @default.
• W2022803933 cites W1671778758 @default.
• W2022803933 cites W1984366394 @default.
• W2022803933 cites W2002092761 @default.
• W2022803933 cites W2024754183 @default.
• W2022803933 cites W2037100155 @default.
• W2022803933 cites W2037632318 @default.
• W2022803933 cites W2042450529 @default.
• W2022803933 cites W2050883852 @default.
• W2022803933 cites W2056987425 @default.
• W2022803933 cites W2061422374 @default.
• W2022803933 cites W2065006357 @default.
• W2022803933 cites W2065844939 @default.
• W2022803933 cites W2084395310 @default.
• W2022803933 cites W2090481553 @default.
• W2022803933 cites W2090609872 @default.
• W2022803933 cites W2093215633 @default.
• W2022803933 cites W2097269513 @default.
• W2022803933 cites W2125572261 @default.
• W2022803933 cites W2128088040 @default.
• W2022803933 cites W2131462541 @default.
• W2022803933 cites W2136189562 @default.
• W2022803933 cites W2143138262 @default.
• W2022803933 cites W2146045461 @default.
• W2022803933 cites W2147898168 @default.
• W2022803933 cites W2413767201 @default.
• W2022803933 doi "https://doi.org/10.1111/j.1365-2249.2005.02894.x" @default.
• W2022803933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809492" @default.
• W2022803933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16178852" @default.
• W2022803933 hasPublicationYear "2005" @default.
• W2022803933 type Work @default.
• W2022803933 sameAs 2022803933 @default.
• W2022803933 citedByCount "20" @default.
• W2022803933 countsByYear W20228039332012 @default.
• W2022803933 countsByYear W20228039332013 @default.
• W2022803933 countsByYear W20228039332016 @default.
• W2022803933 countsByYear W20228039332017 @default.
• W2022803933 crossrefType "journal-article" @default.
• W2022803933 hasAuthorship W2022803933A5030763743 @default.
• W2022803933 hasAuthorship W2022803933A5044316005 @default.
• W2022803933 hasAuthorship W2022803933A5053469409 @default.
• W2022803933 hasAuthorship W2022803933A5082934826 @default.
• W2022803933 hasAuthorship W2022803933A5088144526 @default.
• W2022803933 hasBestOaLocation W20228039332 @default.
• W2022803933 hasConcept C102230213 @default.
• W2022803933 hasConcept C104317684 @default.
• W2022803933 hasConcept C141035611 @default.
• W2022803933 hasConcept C141105273 @default.
• W2022803933 hasConcept C154317977 @default.
• W2022803933 hasConcept C159654299 @default.
• W2022803933 hasConcept C202751555 @default.
• W2022803933 hasConcept C203014093 @default.
• W2022803933 hasConcept C2776090121 @default.
• W2022803933 hasConcept C2778297628 @default.
• W2022803933 hasConcept C2778329239 @default.
• W2022803933 hasConcept C39347974 @default.
• W2022803933 hasConcept C55493867 @default.
• W2022803933 hasConcept C71924100 @default.
• W2022803933 hasConcept C86803240 @default.
• W2022803933 hasConcept C8891405 @default.
• W2022803933 hasConceptScore W2022803933C102230213 @default.
• W2022803933 hasConceptScore W2022803933C104317684 @default.
• W2022803933 hasConceptScore W2022803933C141035611 @default.
• W2022803933 hasConceptScore W2022803933C141105273 @default.
• W2022803933 hasConceptScore W2022803933C154317977 @default.
• W2022803933 hasConceptScore W2022803933C159654299 @default.
• W2022803933 hasConceptScore W2022803933C202751555 @default.
• W2022803933 hasConceptScore W2022803933C203014093 @default.
• W2022803933 hasConceptScore W2022803933C2776090121 @default.
• W2022803933 hasConceptScore W2022803933C2778297628 @default.
• W2022803933 hasConceptScore W2022803933C2778329239 @default.
• W2022803933 hasConceptScore W2022803933C39347974 @default.
• W2022803933 hasConceptScore W2022803933C55493867 @default.
• W2022803933 hasConceptScore W2022803933C71924100 @default.
• W2022803933 hasConceptScore W2022803933C86803240 @default.
• W2022803933 hasConceptScore W2022803933C8891405 @default.
• W2022803933 hasIssue "1" @default.
• W2022803933 hasLocation W20228039331 @default.
• W2022803933 hasLocation W20228039332 @default.
• W2022803933 hasLocation W20228039333 @default.
• W2022803933 hasOpenAccess W2022803933 @default.
• W2022803933 hasPrimaryLocation W20228039331 @default.
• W2022803933 hasRelatedWork W1857920654 @default.
• W2022803933 hasRelatedWork W1967656246 @default.
• W2022803933 hasRelatedWork W2013569000 @default.
• W2022803933 hasRelatedWork W2026268116 @default.
• W2022803933 hasRelatedWork W2031205327 @default.

• next