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• W2022804358 endingPage "363" @default.
• W2022804358 startingPage "353" @default.
• W2022804358 abstract "In Brief Objective: The objective of this study was to determine whether genes that regulate cellular invasion and metastasis are differentially expressed and could serve as diagnostic markers of malignant thyroid nodules. Summary and Background Data: Patients whose thyroid nodules have indeterminate or suspicious cytologic features on fine needle aspiration (FNA) biopsy require thyroidectomy because of a 20% to 30% risk of thyroid cancer. Cell invasion and metastasis is a hallmark of malignant phenotype; therefore, genes that regulate these processes might be differentially expressed and could serve as diagnostic markers of malignancy. Methods: Differentially expressed genes (2-fold higher or lower) in malignant versus benign thyroid neoplasms were identified by extracellular matrix and adhesion molecule cDNA array analysis and confirmed by real-time quantitative polymerase chain reaction (PCR). The area under the receiver operating characteristic (AUC) curve was calculated to determine diagnostic accuracy of gene expression level cutoffs established by logistic regression analysis. Results: By cDNA array analysis, ADAMTS8, ECM1, MMP8, PLAU, SELP, and TMPRSS4 were upregulated, and by quantitative PCR, ECM1, SELP, and TMPRSS4 mRNA expression was higher in malignant (n = 57) than in benign (n = 38) thyroid neoplasms (P< 0.002). ECM1 and TMPRSS4 mRNA expression levels were independent predictors of a malignant thyroid neoplasm (P < 0.003). The AUC was 0.956 for ECM1 and 0.926 for TMPRSS4. Combining both markers improved their diagnostic use (AUC 0.985; sensitivity, 91.7%; specificity, 89.8%; positive predictive value, 85.7%; negative predictive value, 82.8%). ECM1 and TMPRSS4 expression analysis improved the diagnostic accuracy of FNA biopsy in 35 of 38 indeterminate or suspicious results. The level of ECM1 mRNA expression was higher in TNM stage I differentiated thyroid cancers than in stage II and III tumors (P ≤ 0.031). Conclusions: ECM1 and TMPRSS4 are excellent diagnostic markers of malignant thyroid nodules and may be used to improve the diagnostic accuracy of FNA biopsy. ECM1 is also a marker of the extent of disease in differentiated thyroid cancers. Approximately 30% of thyroid nodule fine needle aspiration biopsies are indeterminate, nondiagnostic, or suspicious. To improve diagnostic accuracy, we used cDNA array analysis and quantitative polymerase chain reaction to identify differentially expressed cell invasion and adhesion genes that would be useful diagnostic markers of malignancy. We found that ECM1 and TMPRSS4 were excellent markers of malignant thyroid nodules, and that ECM1 was a marker of extent of disease in differentiated thyroid cancers." @default.
• W2022804358 created "2016-06-24" @default.
• W2022804358 creator A5018781014 @default.
• W2022804358 creator A5052385849 @default.
• W2022804358 creator A5069080473 @default.
• W2022804358 creator A5076916905 @default.
• W2022804358 creator A5078377958 @default.
• W2022804358 creator A5089773064 @default.
• W2022804358 date "2005-09-01" @default.
• W2022804358 modified "2023-10-12" @default.
• W2022804358 title "ECM1 and TMPRSS4 Are Diagnostic Markers of Malignant Thyroid Neoplasms and Improve the Accuracy of Fine Needle Aspiration Biopsy" @default.
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