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- W2022804375 abstract "ABSTRACT This study investigated the effects of perfluorooctane sulfonate (PFOS) exposure for varying durations and at multiple concentrations to Carassius aurats on tissues and organs (plasma, liver, kidney, muscle, and brain) and reproductive hormone (plasma testosterone, 11-ketotestoterone, 17β-estradiol) and cell performance (membrane fluidity and potential), as well as kinetics models. The results showed that plasma PFOS concentrations were higher than those in other tissues, brains presented significantly lower PFOS concentrations than in other tissues, different ranking of mean tissue concentrations: plasma > liver > kidney > muscle > brain. PFOS caused significant decrease in serum cholesterol levels compared to control levels (P <.05). No significant differences in serum cholesterol concentration of male and female Carassius aurats (P >.05). Continuous incubation time induced a further decrease in serum cholesterol in Carassius aurats. Circulating testosterone was significantly depressed in male Carassius aurats with increased PFOS concentration exposure. PFOS in serum of male Carassius aurats was present in a time- and dose-dependent manner, but no significant differences were observed in female Carassius aurats with increased PFOS exposure concentration (P >.05). Circulating 11-ketotestosterone titers were significantly depressed in male Carassius aurats compared to control levels (P <.001), and Carassius aurats exposed to 1.0, 1.5, 2.0, 2.5, and 3.0 mg/L PFOS for 16 days had reduced testosterone levels in males (P ANOVA =.005), but no changes in females. Circulating 17β-estradiol titers in Carassius aurats were reduced with increased PFOS concentration. Exposure to PFOS significantly increased membrane fluidity of Carassius aurats leukocytes; the membrane fluidity was determined to be dose dependent. The highest dose of PFOS was significantly different (P <.05) compared to the lowest concentration in causing effects on membrane potential. Serum PFOS concentrations in male Carassius aurats reached steady-state concentration during the study and that PFOS had a relatively short residence time in serum, with half-lives of 38.5 and 34.3 days for male and female Carassius aurats, respectively." @default.
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- W2022804375 date "2009-01-01" @default.
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- W2022804375 title "Effects of Perfluorooctane Sulfonate on Carassius aurats and Kinetics Models" @default.
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- W2022804375 doi "https://doi.org/10.1080/19430850903149803" @default.
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