FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022805005> ?p ?o ?g. }

• W2022805005 endingPage "6041" @default.
• W2022805005 startingPage "6029" @default.
• W2022805005 abstract "RecQ family helicases are essential in maintaining chromosomal DNA stability and integrity. Despite extensive studies, the mechanisms of these enzymes are still poorly understood. Crystal structures of many helicases reveal a highly conserved arginine residue located near the γ-phosphate of ATP. This residue is widely recognized as an arginine finger, and may sense ATP binding and hydrolysis, and transmit conformational changes. We investigated the existence and role of the arginine finger in the Bloom syndrome protein (BLM), a RecQ family helicase, in ATP hydrolysis and energy coupling. Our studies by combination of structural modelling, site-directed mutagenesis and biochemical and biophysical approaches, demonstrate that mutations of residues interacting with the γ-phosphate of ATP or surrounding the ATP-binding sites result in severe impairment in the ATPase activity of BLM. These mutations also impair BLM's DNA-unwinding activities, but do not affect its ATP and DNA-binding abilities. These data allow us to identify R982 as the residue that functions as a BLM arginine finger. Our findings further indicate how the arginine finger is precisely positioned by the conserved motifs with respect to the γ-phosphate." @default.
• W2022805005 created "2016-06-24" @default.
• W2022805005 creator A5008862465 @default.
• W2022805005 creator A5009837778 @default.
• W2022805005 creator A5015600384 @default.
• W2022805005 creator A5018344454 @default.
• W2022805005 creator A5049874608 @default.
• W2022805005 creator A5062978902 @default.
• W2022805005 creator A5084341155 @default.
• W2022805005 date "2007-08-28" @default.
• W2022805005 modified "2023-10-16" @default.
• W2022805005 title "The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling" @default.
• W2022805005 cites W1855950477 @default.
• W2022805005 cites W1966660027 @default.
• W2022805005 cites W1969530525 @default.
• W2022805005 cites W1982003972 @default.
• W2022805005 cites W1983952649 @default.
• W2022805005 cites W1986104253 @default.
• W2022805005 cites W1989396934 @default.
• W2022805005 cites W1992864103 @default.
• W2022805005 cites W1994718129 @default.
• W2022805005 cites W1996873024 @default.
• W2022805005 cites W2005937630 @default.
• W2022805005 cites W2016862843 @default.
• W2022805005 cites W2025740531 @default.
• W2022805005 cites W2026957636 @default.
• W2022805005 cites W2040695115 @default.
• W2022805005 cites W2044797535 @default.
• W2022805005 cites W2047660022 @default.
• W2022805005 cites W2057808601 @default.
• W2022805005 cites W2057834319 @default.
• W2022805005 cites W2058486409 @default.
• W2022805005 cites W2063335759 @default.
• W2022805005 cites W2065679107 @default.
• W2022805005 cites W2071950147 @default.
• W2022805005 cites W2075909368 @default.
• W2022805005 cites W2082369537 @default.
• W2022805005 cites W2085214569 @default.
• W2022805005 cites W2092615841 @default.
• W2022805005 cites W2098677571 @default.
• W2022805005 cites W2105439835 @default.
• W2022805005 cites W2121749956 @default.
• W2022805005 cites W2122571070 @default.
• W2022805005 cites W2128298547 @default.
• W2022805005 cites W2134103741 @default.
• W2022805005 cites W2135015314 @default.
• W2022805005 cites W2147805925 @default.
• W2022805005 cites W2149443484 @default.
• W2022805005 cites W2151541959 @default.
• W2022805005 cites W2162771144 @default.
• W2022805005 doi "https://doi.org/10.1093/nar/gkm544" @default.
• W2022805005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2094072" @default.
• W2022805005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17766252" @default.
• W2022805005 hasPublicationYear "2007" @default.
• W2022805005 type Work @default.
• W2022805005 sameAs 2022805005 @default.
• W2022805005 citedByCount "15" @default.
• W2022805005 countsByYear W20228050052012 @default.
• W2022805005 countsByYear W20228050052014 @default.
• W2022805005 countsByYear W20228050052015 @default.
• W2022805005 countsByYear W20228050052019 @default.
• W2022805005 countsByYear W20228050052020 @default.
• W2022805005 countsByYear W20228050052021 @default.
• W2022805005 crossrefType "journal-article" @default.
• W2022805005 hasAuthorship W2022805005A5008862465 @default.
• W2022805005 hasAuthorship W2022805005A5009837778 @default.
• W2022805005 hasAuthorship W2022805005A5015600384 @default.
• W2022805005 hasAuthorship W2022805005A5018344454 @default.
• W2022805005 hasAuthorship W2022805005A5049874608 @default.
• W2022805005 hasAuthorship W2022805005A5062978902 @default.
• W2022805005 hasAuthorship W2022805005A5084341155 @default.
• W2022805005 hasBestOaLocation W20228050051 @default.
• W2022805005 hasConcept C104317684 @default.
• W2022805005 hasConcept C107824862 @default.
• W2022805005 hasConcept C12554922 @default.
• W2022805005 hasConcept C130965112 @default.
• W2022805005 hasConcept C134935766 @default.
• W2022805005 hasConcept C141315368 @default.
• W2022805005 hasConcept C161223559 @default.
• W2022805005 hasConcept C16318435 @default.
• W2022805005 hasConcept C181199279 @default.
• W2022805005 hasConcept C23265538 @default.
• W2022805005 hasConcept C2777468819 @default.
• W2022805005 hasConcept C501734568 @default.
• W2022805005 hasConcept C515207424 @default.
• W2022805005 hasConcept C552990157 @default.
• W2022805005 hasConcept C55493867 @default.
• W2022805005 hasConcept C67705224 @default.
• W2022805005 hasConcept C75578959 @default.
• W2022805005 hasConcept C86803240 @default.
• W2022805005 hasConcept C95444343 @default.
• W2022805005 hasConceptScore W2022805005C104317684 @default.
• W2022805005 hasConceptScore W2022805005C107824862 @default.
• W2022805005 hasConceptScore W2022805005C12554922 @default.
• W2022805005 hasConceptScore W2022805005C130965112 @default.
• W2022805005 hasConceptScore W2022805005C134935766 @default.
• W2022805005 hasConceptScore W2022805005C141315368 @default.
• W2022805005 hasConceptScore W2022805005C161223559 @default.

• next