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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022805318> ?p ?o ?g. }

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• W2022805318 abstract "In a large cohort in rural South Africa, 73% of subtype-C-infected patients initiating highly active antiretroviral therapy achieved viral suppression. In patients with subsequent virological failure, an unexpected, rapid accumulation of nonnucleoside reverse transcriptase inhibitor-associated mutations was observed, whereas no thymidine analogue-associated mutations emerged. It appeared that several patients had drug-associated mutations prior to starting antiretrovirals, suggesting that transmission of resistance may have contributed to the accumulation of nonnucleoside reverse transcriptase inhibitor-mutations. Importantly, monitoring of HIV-RNA and prompt switch of treatment may prevent development of thymidine analogue-associated mutations." @default.
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• W2022805318 date "2008-10-18" @default.
• W2022805318 modified "2023-10-02" @default.
• W2022805318 title "Rapid accumulation of nonnucleoside reverse transcriptase inhibitor-associated resistance: evidence of transmitted resistance in rural South Africa" @default.
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• W2022805318 doi "https://doi.org/10.1097/qad.0b013e328313bf87" @default.
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