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• W2022805628 abstract "Functional expression of the K-Cl cotransporter KCC2 in developing central neurons is crucial for the maturation of Cl − -dependent, GABA A receptor-mediated inhibitory responses. In pyramidal neurons of the rodent hippocampus, GABAergic postsynaptic responses are typically depolarizing and often excitatory during the first postnatal week. Here, we show that a single neonatal seizure episode induced by kainate injection during postnatal days 5–7 results in a fast increase in the Cl − extrusion capacity of rat hippocampal CA1 neurons, with a consequent hyperpolarizing shift of the reversal potential of GABA A -mediated currents (E GABA ). A significant increase in the surface expression of KCC2 as well as the α2 subunit of the Na-K-ATPase parallels the seizure-induced increase in the Cl − extrusion capacity. Exposing hippocampal slices to kainate resulted in a similar increase in the neuronal Cl − extrusion and in the surface expression of KCC2. Both effects were blocked by the kinase inhibitor K252a. Hence, in the neonatal hippocampus the overall KCC2 expression level is high enough to promote a rapid functional activation of K-Cl cotransport and a consequent negative shift in E GABA close to the adult level. The activity-dependent regulation of KCC2 function and its effect on GABAergic transmission may represent an intrinsic antiepileptogenic mechanism." @default.
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• W2022805628 date "2010-09-08" @default.
• W2022805628 modified "2023-10-12" @default.
• W2022805628 title "A Single Seizure Episode Leads to Rapid Functional Activation of KCC2 in the Neonatal Rat Hippocampus" @default.
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• W2022805628 doi "https://doi.org/10.1523/jneurosci.3154-10.2010" @default.
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