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- W2022806393 abstract "Using in situ whole-cell patch clamp of hippocampal CA1 pyramidal neurons we demonstrate that glutamate initiates processes resulting in an increase in the amplitude of the excitatory post-synaptic current (EPSC). In adult animals both, NMDA and non-NMDA components of the EPSC increase in parallel. In young animals only the NMDA component is increased. A similar enhancement of the EPSC can be achieved by the stimulation of excitatory synaptic inputs to CA1 neurons with the frequency of the theta-rhythm. EPSCs remain enhanced for more than 60 min. The selective enhancement of the NMDA component in young animals is inhibited by preincubation of slices with the NO-synthase blocker, N omega-nitro-L-arginine (NA) or by the NO-scavenger, hemoglobin." @default.
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- W2022806393 date "1993-03-01" @default.
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- W2022806393 title "Glutamate and θ-rhythm stimulation selectively enhance NMDA component of EPSC in CA1 neurons of young rats" @default.
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- W2022806393 doi "https://doi.org/10.1016/0304-3940(93)90037-l" @default.
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