Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022807726> ?p ?o ?g. }
- W2022807726 endingPage "1360" @default.
- W2022807726 startingPage "1353" @default.
- W2022807726 abstract "To evaluate the immunogenicity of botulinum toxin type A (BoNTA; BOTOX) in cervical dystonia (CD). Subjects diagnosed with CD for ≥1 year and previously naïve to BoNTs were treated with BoNTA in a prospective, open-label, multicenter study. Serum samples were analyzed for BoNTA neutralizing antibodies using the Mouse Protection Assay (MPA). Clinical resistance was assessed with a test injection of 20 U BoNTA placed unilaterally into the frontalis (Frontalis Antibody Test; FTAT) or corrugator muscle (Unilateral Brow Injection; UBI). Efficacy was assessed and adverse events were recorded. Of 326 subjects enrolled, 251 (77%) completed the study. Subjects received a median of 9 BoNTA treatments (mean dose per session ranged from 148.4 to 213.0 U over a mean of 2.5 years [range: 3.2 months–4.2 years]). Only 4 of 326 subjects (1.2%) tested positive for antibodies in the MPA; three of these subjects stopped responding clinically to BoNTA (of whom one also showed clinical resistance in the FTAT) and one continued to respond. Consistent improvements in the signs/symptoms of CD were noted. The most frequent treatment-related adverse events were mild to moderate weakness, dysphagia, neck pain, and injection-site pain. The current formulation of BoNTA rarely causes neutralizing antibody formation in CD subjects treated ≤4 years. © 2008 Movement Disorder Society" @default.
- W2022807726 created "2016-06-24" @default.
- W2022807726 creator A5050167752 @default.
- W2022807726 creator A5055816568 @default.
- W2022807726 creator A5062212464 @default.
- W2022807726 creator A5068655451 @default.
- W2022807726 creator A5088972033 @default.
- W2022807726 date "2008-07-30" @default.
- W2022807726 modified "2023-10-10" @default.
- W2022807726 title "Long-term treatment with botulinum toxin type A in cervical dystonia has low immunogenicity by mouse protection assay" @default.
- W2022807726 cites W1539553781 @default.
- W2022807726 cites W1966004611 @default.
- W2022807726 cites W1966707243 @default.
- W2022807726 cites W1981069875 @default.
- W2022807726 cites W1985296111 @default.
- W2022807726 cites W2003935520 @default.
- W2022807726 cites W2021540050 @default.
- W2022807726 cites W2027142476 @default.
- W2022807726 cites W2034704564 @default.
- W2022807726 cites W2038557164 @default.
- W2022807726 cites W2038588513 @default.
- W2022807726 cites W2043980430 @default.
- W2022807726 cites W2045662349 @default.
- W2022807726 cites W2045927533 @default.
- W2022807726 cites W2050547184 @default.
- W2022807726 cites W2054493369 @default.
- W2022807726 cites W2064629267 @default.
- W2022807726 cites W2068370305 @default.
- W2022807726 cites W2069713889 @default.
- W2022807726 cites W2095561478 @default.
- W2022807726 cites W2121437343 @default.
- W2022807726 cites W2129974957 @default.
- W2022807726 cites W2135481384 @default.
- W2022807726 cites W2153531851 @default.
- W2022807726 cites W4237519055 @default.
- W2022807726 doi "https://doi.org/10.1002/mds.22157" @default.
- W2022807726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18546321" @default.
- W2022807726 hasPublicationYear "2008" @default.
- W2022807726 type Work @default.
- W2022807726 sameAs 2022807726 @default.
- W2022807726 citedByCount "176" @default.
- W2022807726 countsByYear W20228077262012 @default.
- W2022807726 countsByYear W20228077262013 @default.
- W2022807726 countsByYear W20228077262014 @default.
- W2022807726 countsByYear W20228077262015 @default.
- W2022807726 countsByYear W20228077262016 @default.
- W2022807726 countsByYear W20228077262017 @default.
- W2022807726 countsByYear W20228077262018 @default.
- W2022807726 countsByYear W20228077262019 @default.
- W2022807726 countsByYear W20228077262020 @default.
- W2022807726 countsByYear W20228077262021 @default.
- W2022807726 countsByYear W20228077262022 @default.
- W2022807726 countsByYear W20228077262023 @default.
- W2022807726 crossrefType "journal-article" @default.
- W2022807726 hasAuthorship W2022807726A5050167752 @default.
- W2022807726 hasAuthorship W2022807726A5055816568 @default.
- W2022807726 hasAuthorship W2022807726A5062212464 @default.
- W2022807726 hasAuthorship W2022807726A5068655451 @default.
- W2022807726 hasAuthorship W2022807726A5088972033 @default.
- W2022807726 hasConcept C126322002 @default.
- W2022807726 hasConcept C141071460 @default.
- W2022807726 hasConcept C159654299 @default.
- W2022807726 hasConcept C197934379 @default.
- W2022807726 hasConcept C203014093 @default.
- W2022807726 hasConcept C2777478456 @default.
- W2022807726 hasConcept C2777641544 @default.
- W2022807726 hasConcept C2780596822 @default.
- W2022807726 hasConcept C2780868878 @default.
- W2022807726 hasConcept C535046627 @default.
- W2022807726 hasConcept C71924100 @default.
- W2022807726 hasConcept C90924648 @default.
- W2022807726 hasConceptScore W2022807726C126322002 @default.
- W2022807726 hasConceptScore W2022807726C141071460 @default.
- W2022807726 hasConceptScore W2022807726C159654299 @default.
- W2022807726 hasConceptScore W2022807726C197934379 @default.
- W2022807726 hasConceptScore W2022807726C203014093 @default.
- W2022807726 hasConceptScore W2022807726C2777478456 @default.
- W2022807726 hasConceptScore W2022807726C2777641544 @default.
- W2022807726 hasConceptScore W2022807726C2780596822 @default.
- W2022807726 hasConceptScore W2022807726C2780868878 @default.
- W2022807726 hasConceptScore W2022807726C535046627 @default.
- W2022807726 hasConceptScore W2022807726C71924100 @default.
- W2022807726 hasConceptScore W2022807726C90924648 @default.
- W2022807726 hasIssue "10" @default.
- W2022807726 hasLocation W20228077261 @default.
- W2022807726 hasLocation W20228077262 @default.
- W2022807726 hasOpenAccess W2022807726 @default.
- W2022807726 hasPrimaryLocation W20228077261 @default.
- W2022807726 hasRelatedWork W19179184 @default.
- W2022807726 hasRelatedWork W1998077527 @default.
- W2022807726 hasRelatedWork W2013492600 @default.
- W2022807726 hasRelatedWork W2017705908 @default.
- W2022807726 hasRelatedWork W2047179585 @default.
- W2022807726 hasRelatedWork W2069713889 @default.
- W2022807726 hasRelatedWork W2093205405 @default.
- W2022807726 hasRelatedWork W2130361661 @default.
- W2022807726 hasRelatedWork W2237378607 @default.
- W2022807726 hasRelatedWork W2346980695 @default.