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- W2022808864 abstract "Abstract Molecular targeting therapy has recently received attention owing to its high specificity for cancer cells; numerous researchers have been working to identify novel target molecules. In this study, we attempted to identify new targets through cell-based screening with inhibitor panel kits. The growth-inhibitory effects of inhibitors from the Screening Committee of Anticancer Drugs inhibitor kits, which contain 173 chemical inhibitors, were evaluated in oral squamous-cell carcinoma (OSCC) cell lines. Some of the inhibitors strongly suppressed the proliferation of OSCC cells. Of these inhibitors, we chose JSI-124, a specific inhibitor of STAT3, to investigate further. JSI-124 significantly inhibited the growth of OSCC cell lines and then induced DNA fragmentation, poly (ADP-ribose) polymerase cleavage, and caspase 3 activation in a dose-dependent manner. Treatment with JSI-124 resulted in a decrease of phosphorylated STAT3 and a downregulated expression of survivin, a downstream molecule of the STAT3 signaling cascade. Our data suggest that inhibition of STAT3 signaling by JSI-124 might be promising as a molecular therapy strategy against OSCC." @default.
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- W2022808864 date "2011-11-01" @default.
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- W2022808864 title "STAT3 as a target of molecular targeting therapy for oral cancer: Cell-based screening using inhibitor screening kits" @default.
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- W2022808864 doi "https://doi.org/10.1016/j.ajoms.2011.06.007" @default.
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