FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022810014> ?p ?o ?g. }

• W2022810014 endingPage "2777" @default.
• W2022810014 startingPage "2771" @default.
• W2022810014 abstract "Rat 6 cells are not transformed by treatment with the wellknown carcinogens benzo(a)pyrene (BP) or N-methyl-N-nitro-N' nitrosoguanidine (MNNG). Upon retroviral transduction of the mouse c-myc gene, Rat 6 cells showed mildly altered morphology and formed microcolonies in soft agar; furthermore, they could be transformed by BP and MNNG to form large colonies in agar (Hsiao et al. (1992) Mol. Carcinogenesis, 5, 140-154). In the current report, We tested the sensitivity of the c-myc-overexpressing cells (Rat 6/c-myc) to two additional chemicals: 5-azacytidine and MnSO4. These chemicals differ from the direct-acting mutagens tested previously. 5-Azacytidine, a potent DNA methylation inhibitor, induced growth of large colonies in soft agar cultures of Rat 6 or Rat 6/c-myc cells. On the other hand, MnSO4 only induced transformation in Rat 6/c-myc cells, but not the parental Rat 6 cells. Transformants induced by 5-azacytidine lost c-myc-induced apoptotic cell death, whereas degree MnSO4 induced transformants showed a higher degree of apoptosis than the parental Rat 6/c-myc cells.These results suggest that MnSO4 co-operates with over-expressed c-myc in including transformation, while 5-azacytidine transformetion and may involve alterations in the regulation of apoptosis." @default.
• W2022810014 created "2016-06-24" @default.
• W2022810014 creator A5019250702 @default.
• W2022810014 creator A5044265499 @default.
• W2022810014 creator A5048886337 @default.
• W2022810014 creator A5089477496 @default.
• W2022810014 date "1996-01-01" @default.
• W2022810014 modified "2023-10-17" @default.
• W2022810014 title "Comparison of transformation by manganese sulfate and 5-azacytidine in Rat 6 cells overexpressing the <i>c-myc</i> oncogene" @default.
• W2022810014 cites W1525972653 @default.
• W2022810014 cites W1606972408 @default.
• W2022810014 cites W1791922283 @default.
• W2022810014 cites W1794715699 @default.
• W2022810014 cites W1810581042 @default.
• W2022810014 cites W1993257224 @default.
• W2022810014 cites W2038786311 @default.
• W2022810014 cites W2073503003 @default.
• W2022810014 cites W2078715725 @default.
• W2022810014 cites W2081948388 @default.
• W2022810014 cites W2088665501 @default.
• W2022810014 cites W2093374807 @default.
• W2022810014 cites W2096244703 @default.
• W2022810014 cites W2152999005 @default.
• W2022810014 cites W2259290285 @default.
• W2022810014 cites W2417371800 @default.
• W2022810014 doi "https://doi.org/10.1093/carcin/17.12.2771" @default.
• W2022810014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9006118" @default.
• W2022810014 hasPublicationYear "1996" @default.
• W2022810014 type Work @default.
• W2022810014 sameAs 2022810014 @default.
• W2022810014 citedByCount "3" @default.
• W2022810014 crossrefType "journal-article" @default.
• W2022810014 hasAuthorship W2022810014A5019250702 @default.
• W2022810014 hasAuthorship W2022810014A5044265499 @default.
• W2022810014 hasAuthorship W2022810014A5048886337 @default.
• W2022810014 hasAuthorship W2022810014A5089477496 @default.
• W2022810014 hasBestOaLocation W20228100141 @default.
• W2022810014 hasConcept C104317684 @default.
• W2022810014 hasConcept C114246631 @default.
• W2022810014 hasConcept C150194340 @default.
• W2022810014 hasConcept C153911025 @default.
• W2022810014 hasConcept C190283241 @default.
• W2022810014 hasConcept C190727270 @default.
• W2022810014 hasConcept C204241405 @default.
• W2022810014 hasConcept C2777538855 @default.
• W2022810014 hasConcept C2780625556 @default.
• W2022810014 hasConcept C2781018059 @default.
• W2022810014 hasConcept C29537977 @default.
• W2022810014 hasConcept C31033888 @default.
• W2022810014 hasConcept C33288867 @default.
• W2022810014 hasConcept C501734568 @default.
• W2022810014 hasConcept C502942594 @default.
• W2022810014 hasConcept C54355233 @default.
• W2022810014 hasConcept C552990157 @default.
• W2022810014 hasConcept C55493867 @default.
• W2022810014 hasConcept C555283112 @default.
• W2022810014 hasConcept C81885089 @default.
• W2022810014 hasConcept C86803240 @default.
• W2022810014 hasConceptScore W2022810014C104317684 @default.
• W2022810014 hasConceptScore W2022810014C114246631 @default.
• W2022810014 hasConceptScore W2022810014C150194340 @default.
• W2022810014 hasConceptScore W2022810014C153911025 @default.
• W2022810014 hasConceptScore W2022810014C190283241 @default.
• W2022810014 hasConceptScore W2022810014C190727270 @default.
• W2022810014 hasConceptScore W2022810014C204241405 @default.
• W2022810014 hasConceptScore W2022810014C2777538855 @default.
• W2022810014 hasConceptScore W2022810014C2780625556 @default.
• W2022810014 hasConceptScore W2022810014C2781018059 @default.
• W2022810014 hasConceptScore W2022810014C29537977 @default.
• W2022810014 hasConceptScore W2022810014C31033888 @default.
• W2022810014 hasConceptScore W2022810014C33288867 @default.
• W2022810014 hasConceptScore W2022810014C501734568 @default.
• W2022810014 hasConceptScore W2022810014C502942594 @default.
• W2022810014 hasConceptScore W2022810014C54355233 @default.
• W2022810014 hasConceptScore W2022810014C552990157 @default.
• W2022810014 hasConceptScore W2022810014C55493867 @default.
• W2022810014 hasConceptScore W2022810014C555283112 @default.
• W2022810014 hasConceptScore W2022810014C81885089 @default.
• W2022810014 hasConceptScore W2022810014C86803240 @default.
• W2022810014 hasIssue "12" @default.
• W2022810014 hasLocation W20228100141 @default.
• W2022810014 hasLocation W20228100142 @default.
• W2022810014 hasOpenAccess W2022810014 @default.
• W2022810014 hasPrimaryLocation W20228100141 @default.
• W2022810014 hasRelatedWork W1942624055 @default.
• W2022810014 hasRelatedWork W1978665041 @default.
• W2022810014 hasRelatedWork W1987008525 @default.
• W2022810014 hasRelatedWork W2055921089 @default.
• W2022810014 hasRelatedWork W2157427261 @default.
• W2022810014 hasRelatedWork W2384204931 @default.
• W2022810014 hasRelatedWork W2410197918 @default.
• W2022810014 hasRelatedWork W2417475048 @default.
• W2022810014 hasRelatedWork W2602787945 @default.
• W2022810014 hasRelatedWork W2589109409 @default.
• W2022810014 hasVolume "17" @default.
• W2022810014 isParatext "false" @default.
• W2022810014 isRetracted "false" @default.
• W2022810014 magId "2022810014" @default.

• next